PMID- 26604527
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20220318
IS  - 0974-2700 (Print)
IS  - 0974-519X (Electronic)
IS  - 0974-2700 (Linking)
VI  - 8
IP  - 4
DP  - 2015 Oct-Dec
TI  - Adverse events and outcomes of procedural sedation and analgesia in major trauma 
      patients.
PG  - 210-5
LID - 10.4103/0974-2700.166612 [doi]
AB  - CONTEXT: Trauma patients requiring procedural sedation and analgesia (PSA) may 
      have increased risk of adverse events (AEs) and poor outcomes. AIMS: To determine 
      the incidence of AEs in adult major trauma patients who received PSA and to 
      evaluate their postprocedural outcomes. SETTINGS AND DESIGN: Retrospective 
      analysis of adult patients (age >16) who received PSA between 2006 and 2014 at a 
      Canadian academic tertiary care center. MATERIALS AND METHODS: We compared the 
      incidence of PSA-related AEs in trauma patients with nontrauma patients. 
      Postprocedural outcomes including Intensive Care Unit admission, length of 
      hospital stay, and mortality were compared between trauma patients who did or did 
      not receive PSA. STATISTICAL ANALYSIS USED: Descriptive statistics and 
      multivariable logistic regression. RESULTS: Overall, 4324 patients received PSA 
      during their procedure, of which 101 were trauma patients (107 procedures). The 
      majority (77%) of these 101 trauma patients were male, relatively healthy (78% 
      with American Society of Anesthesiologists Physical Status [ASA-PS] 1), and most 
      (85%) of the 107 procedures were orthopedic manipulations. PSA-related AEs were 
      experienced by 45.5% of the trauma group and 45.9% of the nontrauma group. In the 
      trauma group, the most common AEs were tachypnea (23%) and hypotension (20%). 
      After controlling for age, gender, and ASA-PS, trauma patients were more likely 
      than nontrauma patients to develop hypotension (odds ratio 1.79; 95% confidence 
      interval 1.11-2.89). CONCLUSION: Although trauma patients were more likely than 
      nontrauma patients to develop hypotension during PSA, their outcomes were not 
      worse compared to trauma patients who did not have PSA.
FAU - Green, Robert S
AU  - Green RS
AD  - Department of Emergency Medicine, Dalhousie University, Halifax, NS, Canada ; 
      Department of Critical Care Medicine, Dalhousie University, Halifax, NS, Canada ; 
      Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, 
      Canada.
FAU - Butler, Michael B
AU  - Butler MB
AD  - Department of Critical Care Medicine, Dalhousie University, Halifax, NS, Canada ; 
      Department of Mathematics and Statistics, Dalhousie University, Halifax, NS, 
      Canada.
FAU - Campbell, Samuel G
AU  - Campbell SG
AD  - Department of Emergency Medicine, Dalhousie University, Halifax, NS, Canada.
FAU - Erdogan, Mete
AU  - Erdogan M
AD  - Department of Trauma Nova Scotia, Halifax, NS, Canada.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Emerg Trauma Shock
JT  - Journal of emergencies, trauma, and shock
JID - 101493921
PMC - PMC4626938
OTO - NOTNLM
OT  - Analgesia
OT  - outcomes
OT  - procedural
OT  - retrospective
OT  - sedation
OT  - trauma
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/10/01
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - JETS-8-210 [pii]
AID - 10.4103/0974-2700.166612 [doi]
PST - ppublish
SO  - J Emerg Trauma Shock. 2015 Oct-Dec;8(4):210-5. doi: 10.4103/0974-2700.166612.