PMID- 26604566
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20220317
IS  - 0976-237X (Print)
IS  - 0976-2361 (Electronic)
IS  - 0976-2361 (Linking)
VI  - 6
IP  - Suppl 1
DP  - 2015 Sep
TI  - Estimation of salivary tumor necrosis factor-alpha in chronic and aggressive 
      periodontitis patients.
PG  - S152-6
LID - 10.4103/0976-237X.166816 [doi]
AB  - INTRODUCTION: Periodontitis is a chronic bacterial infection characterized by 
      persistent inflammation, connective tissue breakdown and alveolar bone 
      destruction mediated by pro-inflammatory mediators. Tumor necrosis factor-alpha 
      (TNF-alpha) is an important pro-inflammatory mediator that produced causes 
      destruction of periodontal tissues. OBJECTIVE: The aim of the study is to 
      estimate the salivary TNF-alpha in chronic and aggressive periodontitis and control 
      participants and further correlate the levels with clinical parameter such as 
      gingival index (GI), plaque index (PI), probing pocket depth (PPD) and clinical 
      attachment loss. MATERIALS AND METHODS: The study population consisted of 75 
      subjects age ranging from 25 to 55 years attending the outpatient section of 
      Department of Periodontics, Saveetha Dental College and Hospital. The study 
      groups included Groups 1, 2, and 3 with participants with healthy periodontium (n 
      = 25), generalized chronic periodontitis (n = 25) and generalized aggressive 
      periodontitis (n = 25), respectively. Salivary samples from the participants were 
      used to assess the TNF-alpha levels using enzyme-linked immunosorbent assay. RESULTS: 
      GI and PI were found to be significantly higher in chronic and aggressive 
      periodontitis compared to the controls. The mean TNF-alpha value in chronic 
      periodontitis patients (12.92 +/- 17.21 pg/ml) was significantly higher than in 
      control subjects (2.15 +/- 3.60 pg/ml). Whereas, in aggressive periodontitis 
      patients the mean TNF-alpha (7.23 +/- 7.67) were not significantly different from 
      chronic periodontitis or healthy subjects. Among periodontitis participants, 
      aggressive periodontitis subjects exhibited a significant positive correlation 
      between the salivary TNF-alpha and PPD. CONCLUSION: Salivary TNF-alpha levels are 
      significantly higher in chronic periodontitis than in healthy subjects, but there 
      was no significant correlation with the clinical parameters.
FAU - Varghese, Sheeja S
AU  - Varghese SS
AD  - Department of Periodontology, Saveetha Dental College and Hospital, Chennai, 
      Tamil Nadu, India.
FAU - Thomas, Hima
AU  - Thomas H
AD  - Department of Periodontology, Saveetha Dental College and Hospital, Chennai, 
      Tamil Nadu, India.
FAU - Jayakumar, N D
AU  - Jayakumar ND
AD  - Department of Periodontology, Saveetha Dental College and Hospital, Chennai, 
      Tamil Nadu, India.
FAU - Sankari, M
AU  - Sankari M
AD  - Department of Periodontology, Saveetha Dental College and Hospital, Chennai, 
      Tamil Nadu, India.
FAU - Lakshmanan, Reema
AU  - Lakshmanan R
AD  - Department of Periodontology, Saveetha Dental College and Hospital, Chennai, 
      Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Contemp Clin Dent
JT  - Contemporary clinical dentistry
JID - 101552967
PMC - PMC4632215
OTO - NOTNLM
OT  - Aggressive periodontitis
OT  - chronic periodontitis
OT  - cytokines
OT  - tumor necrosis factor-alpha
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/09/01
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - CCD-6-152 [pii]
AID - 10.4103/0976-237X.166816 [doi]
PST - ppublish
SO  - Contemp Clin Dent. 2015 Sep;6(Suppl 1):S152-6. doi: 10.4103/0976-237X.166816.