PMID- 26604816
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20220331
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 8
DP  - 2015
TI  - An integrated safety analysis of intravenous ibuprofen (Caldolor((R))) in adults.
PG  - 753-65
LID - 10.2147/JPR.S93547 [doi]
AB  - Intravenous (IV) nonsteroidal anti-inflammatory drugs such as IV ibuprofen are 
      increasingly used as a component of multimodal pain management in the inpatient 
      and outpatient settings. The safety of IV ibuprofen as assessed in ten sponsored 
      clinical studies is presented in this analysis. Overall, 1,752 adult patients 
      have been included in safety and efficacy trials over 11 years; 1,220 of these 
      patients have received IV ibuprofen and 532 received either placebo or comparator 
      medication. The incidence of adverse events (AEs), serious AEs, and changes in 
      vital signs and clinically significant laboratory parameters have been summarized 
      and compared to patients receiving placebo or active comparator drug. Overall, IV 
      ibuprofen has been well tolerated by hospitalized and outpatient patients when 
      administered both prior to surgery and postoperatively as well as for nonsurgical 
      pain or fever. The overall incidence of AEs is lower in patients receiving IV 
      ibuprofen as compared to those receiving placebo in this integrated analysis. 
      Specific analysis of hematological and renal effects showed no increased risk for 
      patients receiving IV ibuprofen. A subset analysis of elderly patients suggests 
      that no dose adjustment is needed in this higher risk population. This integrated 
      safety analysis demonstrates that IV ibuprofen can be safely administered prior 
      to surgery and continued in the postoperative period as a component of multimodal 
      pain management.
FAU - Southworth, Stephen R
AU  - Southworth SR
AD  - North Mississippi Sports Medicine and Orthopaedic Clinic, PLLC, Tupelo, MS, USA.
FAU - Woodward, Emily J
AU  - Woodward EJ
AD  - Department of Research and Development, Cumberland Pharmaceuticals Inc., 
      Nashville, TN, USA.
FAU - Peng, Alex
AU  - Peng A
AD  - Department of Research and Development, Cumberland Pharmaceuticals Inc., 
      Nashville, TN, USA.
FAU - Rock, Amy D
AU  - Rock AD
AD  - Department of Research and Development, Cumberland Pharmaceuticals Inc., 
      Nashville, TN, USA.
LA  - eng
PT  - Journal Article
DEP - 20151023
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC4631431
OTO - NOTNLM
OT  - NSAID
OT  - critical care
OT  - fever
OT  - multimodal pain management
OT  - perioperative analgesia
OT  - surgical pain
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/10/23
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/10/23 00:00 [pmc-release]
AID - jpr-8-753 [pii]
AID - 10.2147/JPR.S93547 [doi]
PST - epublish
SO  - J Pain Res. 2015 Oct 23;8:753-65. doi: 10.2147/JPR.S93547. eCollection 2015.