PMID- 26604903
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20200930
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 10
IP  - 9
DP  - 2015 Sep
TI  - Overexpression of brain-derived neurotrophic factor in the hippocampus protects 
      against post-stroke depression.
PG  - 1427-32
LID - 10.4103/1673-5374.165510 [doi]
AB  - Post-stroke depression is associated with reduced expression of brain-derived 
      neurotrophic factor (BDNF). In this study, we evaluated whether BDNF 
      overexpression affects depression-like behavior in a rat model of post-stroke 
      depression. The middle cerebral artery was occluded to produce a model of focal 
      cerebral ischemia. These rats were then subjected to isolation-housing combined 
      with chronic unpredictable mild stress to generate a model of post-stroke 
      depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 
      days after injection, western blot assay and real-time quantitative PCR revealed 
      that BDNF expression in the hippocampus was increased in depressive rats injected 
      with BDNF lentivirus compared with depressive rats injected with control vector. 
      Furthermore, sucrose solution consumption was higher, and horizontal and vertical 
      movement scores were increased in the open field test in these rats as well. 
      These findings suggest that BDNF overexpression in the hippocampus of post-stroke 
      depressive rats alleviates depression-like behaviors.
FAU - Chen, Hao-Hao
AU  - Chen HH
AD  - Medical Molecular Biology Laboratory, School of Medicine, Jinhua Polytechnic, 
      Jinhua, Zhejiang Province, China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - Medical Molecular Biology Laboratory, School of Medicine, Jinhua Polytechnic, 
      Jinhua, Zhejiang Province, China.
FAU - Li, Wei-Yun
AU  - Li WY
AD  - Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 
      Zhejiang Province, China.
FAU - Fang, Ma-Rong
AU  - Fang MR
AD  - Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 
      Zhejiang Province, China.
FAU - Zhang, Hui
AU  - Zhang H
AD  - Center of Experimental Animals, Jinhua Food and Drug Administration, Jinhua, 
      Zhejiang Province, China.
FAU - Fang, Yuan-Shu
AU  - Fang YS
AD  - Center of Experimental Animals, Jinhua Food and Drug Administration, Jinhua, 
      Zhejiang Province, China.
FAU - Ding, Ming-Xing
AU  - Ding MX
AD  - Medical Molecular Biology Laboratory, School of Medicine, Jinhua Polytechnic, 
      Jinhua, Zhejiang Province, China.
FAU - Fu, Xiao-Yan
AU  - Fu XY
AUID- ORCID: 0000-0001-5496-7944
AD  - Medical Molecular Biology Laboratory, School of Medicine, Jinhua Polytechnic, 
      Jinhua, Zhejiang Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC4625508
OTO - NOTNLM
OT  - brain injury
OT  - brain-derived neurotrophic factor
OT  - cerebral ischemia
OT  - chronic unpredictable mild stress
OT  - depression-like behavior
OT  - hippocampus
OT  - lentivirus
OT  - nerve regeneration
OT  - neural regeneration
OT  - open field test
OT  - post-stroke depression
OT  - sucrose solution consumption
OT  - western blot assay
COIS- Conflicts of interest: None declared.
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/09/01
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - NRR-10-1427 [pii]
AID - 10.4103/1673-5374.165510 [doi]
PST - ppublish
SO  - Neural Regen Res. 2015 Sep;10(9):1427-32. doi: 10.4103/1673-5374.165510.