PMID- 26604959
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20200930
IS  - 1735-3327 (Print)
IS  - 2008-0255 (Electronic)
IS  - 1735-3327 (Linking)
VI  - 12
IP  - 5
DP  - 2015 Sep-Oct
TI  - Inflammatory markers in gingival crevicular fluid of periodontitis patients with 
      type 2 diabetes mellitus according to glycemic control: A pilot study.
PG  - 449-55
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and periodontitis are inflammatory 
      conditions with a bidirectional association. This pilot study aimed to evaluate 
      whether T2DM and glycemic control interfere in inflammatory markers profiles in 
      gingival crevicular fluid (GCF) in periodontitis patients. MATERIALS AND METHODS: 
      Fourteen diabetic periodontitis patients were enrolled in this study, seven with 
      adequate glycemic control (glycated hemoglobin [HbA1c] <8.0%) (DMA + P) and seven 
      with inadequate control (HbA1c >/=8.0%) (DMI + P). Seven chronic periodontitis 
      patients without diabetes formed the control group (P). GCF was obtained from 
      diseased sites (probing depth >6 mm) of an entirely hemiarch, pooled and 
      cytokines levels determined using multiplex beads immunoassay. Clinical 
      periodontal parameters were analyzed by Mann-Whitney test and levels of cytokines 
      by Kruskal-Wallis and Dunn's multiple comparison tests with confidence level of 
      95% (P < 0.05). RESULTS: Cytokines profile of GCF obtained from deep periodontal 
      pockets presented high levels of inflammatory cytokines, and there were no 
      statistical differences between levels of interleukin-6 (IL-6), IL-8 and tumor 
      necrosis factor-alpha according to presence of diabetes or percentage of HbA1c among 
      the groups, despite groups with T2DM and periodontitis exhibit higher levels of 
      PD. CONCLUSION: Within the limitations of this study, inflammatory mediators in 
      GCF are dependent to the local response and do not correlate with the diabetic 
      status.
FAU - Longo, Priscila Larcher
AU  - Longo PL
AD  - Department of Microbiology, Institute of Biomedical Sciences, University of Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Artese, Hilana Paula Carilo
AU  - Artese HP
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Horliana, Anna Carolina Ratto Tempestini
AU  - Horliana AC
AD  - Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho 
      University, Sao Paulo, Brazil.
FAU - Gomes, Giovane Hisse
AU  - Gomes GH
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Romito, Giuseppe Alexandre
AU  - Romito GA
AD  - Department of Stomatology, Division of Periodontics, School of Dentistry, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Dib, Sergio Atala
AU  - Dib SA
AD  - Department of Endocrinology, School of Medicine, Federal University of Sao Paulo, 
      Sao Paulo, Brazil.
FAU - Mayer, Marcia Pinto Alves
AU  - Mayer MP
AD  - Department of Microbiology, Institute of Biomedical Sciences, University of Sao 
      Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Dent Res J (Isfahan)
JT  - Dental research journal
JID - 101471186
PMC - PMC4630709
OTO - NOTNLM
OT  - Cytokines
OT  - diabetes mellitus
OT  - gingival crevicular fluid
OT  - inflammation
OT  - periodontitis
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/09/01
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - DRJ-12-449 [pii]
AID - 10.4103/1735-3327.166193 [doi]
PST - ppublish
SO  - Dent Res J (Isfahan). 2015 Sep-Oct;12(5):449-55. doi: 10.4103/1735-3327.166193.