PMID- 26605240
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151125
LR  - 20200930
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 4
DP  - 2015
TI  - The effect of add-on memantine on global function and quality of life in 
      schizophrenia: A randomized, double-blind, controlled, clinical trial.
PG  - 211
LID - 10.4103/2277-9175.166148 [doi]
LID - 211
AB  - BACKGROUND: Schizophrenia severely influences function and quality of life. The 
      benefit of newer antipsychotics in improving the quality of life in schizophrenia 
      still remains controversial. The aim of the present study is to evaluate the 
      effect of memantine on global function and quality of life in patients with 
      schizophrenia. MATERIALS AND METHODS: This was a randomized controlled trial on 
      inpatient cases of schizophrenia in Noor University Hospital, Isfahan, Iran. A 
      number of 64 patients were selected through sequential sampling; patients were 
      randomly allocated in intervention and placebo groups. The intervention group was 
      treated with memantine plus previously administered, stabled-dose, atypical 
      antipsychotic, while the control group received placebo plus previously 
      administered, stabled-dose, atypical antipsychotic. Memantine administration was 
      initiated at 5 mg daily; the dosage was increased at weekly intervals by 5 mg and 
      finally up-titrated to 20 mg daily within 4 weeks. All patients were assessed by 
      means of Global Assessment of Functioning (GAF) and quality of life scale (QLS) 
      initially and every four weeks to the end of the 12(th) week. RESULTS: Analysis 
      of baseline GAF and QLS scores showed no significant differences between the two 
      groups (P = 0.081 and P = 0.225, respectively). GAF and QLS scores increased in 
      both groups; but it was higher in the intervention group. The difference between 
      the two groups was statistically significant. (P < 0.001 and P < 0.001, 
      respectively) memantine was well tolerated, with no significant side effects. 
      CONCLUSION: Add-on memantine was significantly effective in improving the global 
      function of patients as well as their quality of life.
FAU - Omranifard, Victoria
AU  - Omranifard V
AD  - Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University 
      of Medical Sciences, Isfahan, Iran.
FAU - Rajabi, Fatemeh
AU  - Rajabi F
AD  - Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University 
      of Medical Sciences, Isfahan, Iran.
FAU - Mohammadian-Sichani, Maryam
AU  - Mohammadian-Sichani M
AD  - Department of Psychiatry, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Maracy, Mohammad
AU  - Maracy M
AD  - Department of Epidemiology, Psychosomatic Research Center, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150928
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC4627187
OTO - NOTNLM
OT  - Function
OT  - global assessment of functioning
OT  - memantine
OT  - quality of life
OT  - quality of life scale
OT  - schizophrenia
EDAT- 2015/11/26 06:00
MHDA- 2015/11/26 06:01
PMCR- 2015/09/28
CRDT- 2015/11/26 06:00
PHST- 2014/12/07 00:00 [received]
PHST- 2015/03/09 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2015/11/26 06:01 [medline]
PHST- 2015/09/28 00:00 [pmc-release]
AID - ABR-4-211 [pii]
AID - 10.4103/2277-9175.166148 [doi]
PST - epublish
SO  - Adv Biomed Res. 2015 Sep 28;4:211. doi: 10.4103/2277-9175.166148. eCollection 
      2015.