PMID- 26606308
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20180424
IS  - 1873-4235 (Electronic)
IS  - 0956-5663 (Linking)
VI  - 78
DP  - 2016 Apr 15
TI  - Cubic Cu2O nanoframes with a unique edge-truncated structure and a good 
      electrocatalytic activity for immunosensor application.
PG  - 167-173
LID - S0956-5663(15)30593-5 [pii]
LID - 10.1016/j.bios.2015.11.036 [doi]
AB  - In this work, an ultrasensitive sandwich-type electrochemical immunosensor was 
      developed for the quantitative detection of prostate specific antigen (PSA). Gold 
      nanoparticles decorated 3-aminopropyltriethoxysilane functionalized graphene 
      sheets (Au@APTES-GS) with a large specific surface area, good biocompatibility 
      and superior electron transfer ability were employed as the matrix. In addition, 
      cubic Cu2O nanoframes with hollow edges were employed as the label for the first 
      time. Scanning electron microscope (SEM) images were used to confirm the 
      nanostructure of Au@APTES-GS and Cu2O. Using square wave voltammetry (SWV) to 
      monitor the electrocatalytic process, the signal amplification mechanism of the 
      matrix and the label were explored successfully. Here we find that the unique 
      edge-truncated structure of Cu2O nanoframes can load with a larger amount of 
      redox mediators, ferrocenecarboxylic acid (Fc-COOH), offering a higher 
      electrochemical signal response. Apart from that, Cu2O nanoframes have a good 
      electrocatalytic activity towards the Fc-COOH and hydrogen peroxide (H2O2), 
      making a contribution to further enhance the sensitivity of the fabricated 
      immunosensor. Under optimal conditions, the proposed immunosensor achieved an 
      ultrasensitive and specific detection of PSA, and displayed acceptable 
      reproducibility, selectivity and stability. This work may provide an effective 
      method for the clinical monitoring of tumor markers and demonstrate the potential 
      application promising of nanoframes in the fabrication of immunosensors.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ma, Hongmin
AU  - Ma H
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Li, Yan
AU  - Li Y
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Wang, Yulan
AU  - Wang Y
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Hu, Lihua
AU  - Hu L
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Zhang, Yong
AU  - Zhang Y
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Fan, Dawei
AU  - Fan D
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Yan, Tao
AU  - Yan T
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China.
FAU - Wei, Qin
AU  - Wei Q
AD  - Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School 
      of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR 
      China. Electronic address: sdjndxwq@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151114
PL  - England
TA  - Biosens Bioelectron
JT  - Biosensors & bioelectronics
JID - 9001289
RN  - 0 (Antibodies, Immobilized)
RN  - 0 (Biomarkers, Tumor)
RN  - 7440-57-5 (Gold)
RN  - 7782-42-5 (Graphite)
RN  - 789U1901C5 (Copper)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
RN  - T8BEA5064F (cuprous oxide)
SB  - IM
MH  - Antibodies, Immobilized/chemistry/immunology
MH  - Biomarkers, Tumor/immunology/*isolation & purification
MH  - *Biosensing Techniques
MH  - Copper/chemistry
MH  - Electrochemical Techniques/*methods
MH  - Gold/chemistry
MH  - Graphite/chemistry
MH  - Humans
MH  - Hydrogen Peroxide/chemistry
MH  - Immunoassay
MH  - Metal Nanoparticles/chemistry
MH  - Prostate-Specific Antigen/chemistry/*isolation & purification
OTO - NOTNLM
OT  - Electrocatalytic activity
OT  - Ferrocenecarboxylic acid
OT  - Immunosensor
OT  - Nanoframes
OT  - Prostate specific antigen
EDAT- 2015/11/26 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/09/12 00:00 [received]
PHST- 2015/10/27 00:00 [revised]
PHST- 2015/11/13 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - S0956-5663(15)30593-5 [pii]
AID - 10.1016/j.bios.2015.11.036 [doi]
PST - ppublish
SO  - Biosens Bioelectron. 2016 Apr 15;78:167-173. doi: 10.1016/j.bios.2015.11.036. 
      Epub 2015 Nov 14.