PMID- 26606429
OWN - NLM
STAT- MEDLINE
DCOM- 20170602
LR  - 20220408
IS  - 1528-1140 (Electronic)
IS  - 0003-4932 (Linking)
VI  - 264
IP  - 6
DP  - 2016 Dec
TI  - Ligation of Intersphincteric Fistula Tract vs Ligation of the Intersphincteric 
      Fistula Tract Plus a Bioprosthetic Anal Fistula Plug Procedure in Patients With 
      Transsphincteric Anal Fistula: Early Results of a Multicenter Prospective 
      Randomized Trial.
PG  - 917-922
AB  - OBJECTIVE: The purpose of this study was to compare the ligation of 
      intersphincteric fistula tract (LIFT) with an additional plug (LIFT-plug) in the 
      treatment of transsphincteric anal fistula. SUMMARY BACKGROUND DATA: Both LIFT 
      and LIFT-plug are recently reported effective alternatives of transsphincteric 
      anal fistula. METHODS: This multicenter prospective randomized study 
      (NCT01478139) was conducted at 5 university hospitals throughout China. A total 
      of 235 patients were randomly assigned to undergo LIFT (118 patients) or 
      LIFT-plug (117 patients) between March 2011 and April 2013. The primary outcome 
      measured was primary healing rate at 6 months postoperatively and healing time. 
      Secondary outcomes included recurrence rate, postoperative pain, and incontinence 
      rate. RESULTS: The LIFT procedure showed shorter operative time than the 
      LIFT-plug procedure (26.7 min vs 28.5 min, P = 0.03). Median healing time was 22 
      days in LIFT-plug group vs 30 days in LIFT group (P < 0.001). The difference in 
      visual analog scale scores across all time points was not statistically 
      significant between the groups (P = 0.13). The primary healing rate was higher in 
      LIFT-plug group than in LIFT group [94.0% (95% confidence interval 89.7%-98.3%) 
      vs 83.9% (95% confidence interval 77.2%-90.6%), P < 0.001]. There were no 
      reported incontinence and recurrence within the follow-up period of 6 months. 
      CONCLUSIONS: In patients with transsphincteric anal fistulas, both LIFT-plug and 
      LIFT are simple, safe, and effective procedures. LIFT-plug has the advantage of a 
      higher healing rate, less healing time, and a lower early postoperative pain 
      score.
FAU - Han, Jia Gang
AU  - Han JG
AD  - *Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical 
      Univerisity, Beijing, People's Republic of ChinadaggerDepartment of General Surgery, 
      Peking University Third Hosptial, Beijing, People's Republic of Chinadouble daggerDepartment 
      of General Surgery, Shanxi Provincial People's Hospital, Shaanxi, People's 
      Republic of China section signDepartment of General Surgery, The First Affiliated Hospital of 
      the School of Medicine Xi An Jiaotong University, Shaanxi, People's Republic of 
      China paragraph signDepartment of General Surgery, Tianjin Third Central Hospital, Tianjin, 
      People's Republic of China.
FAU - Wang, Zhen Jun
AU  - Wang ZJ
FAU - Zheng, Yi
AU  - Zheng Y
FAU - Chen, Chao Wen
AU  - Chen CW
FAU - Wang, Xiao Qiang
AU  - Wang XQ
FAU - Che, Xiang Ming
AU  - Che XM
FAU - Song, Wei Liang
AU  - Song WL
FAU - Cui, Jin Jie
AU  - Cui JJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Ann Surg
JT  - Annals of surgery
JID - 0372354
SB  - IM
MH  - Adult
MH  - Bioprosthesis
MH  - China
MH  - Fecal Incontinence/epidemiology
MH  - Female
MH  - Humans
MH  - Ligation
MH  - Male
MH  - Operative Time
MH  - Pain, Postoperative/epidemiology
MH  - Prospective Studies
MH  - Rectal Fistula/*surgery
MH  - Recurrence
MH  - Treatment Outcome
MH  - Urinary Incontinence/epidemiology
MH  - Wound Healing
EDAT- 2015/11/26 06:00
MHDA- 2017/06/03 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2017/06/03 06:00 [medline]
PHST- 2015/11/26 06:00 [entrez]
AID - 10.1097/SLA.0000000000001562 [doi]
PST - ppublish
SO  - Ann Surg. 2016 Dec;264(6):917-922. doi: 10.1097/SLA.0000000000001562.