PMID- 26606689
OWN - NLM
STAT- MEDLINE
DCOM- 20161107
LR  - 20181202
IS  - 1365-2672 (Electronic)
IS  - 1364-5072 (Linking)
VI  - 120
IP  - 2
DP  - 2016 Feb
TI  - Linoleic acid salt with ultrapure soft water as an antibacterial combination 
      against dermato-pathogenic Staphylococcus spp.
PG  - 280-8
LID - 10.1111/jam.13012 [doi]
AB  - AIMS: Skin colonization of Staphylococcus spp. critically affects the severity of 
      dermatitis in humans and animals. We examined different types of fatty acid salts 
      for their antibacterial activity against Staphylococcus spp. when used in 
      ultrapure soft water (UPSW). We also evaluated their therapeutic effect on a 
      spontaneous canine model of dermatitis. METHODS AND RESULTS: UPSW, in which 
      Ca(++) and Mg(++) were replaced with Na(+) , was generated using a water softener 
      with cation-exchange resin. Staphylococcus aureus (Staph. aureus), Staphylococcus 
      intermedius (Staph. intermedius), and Staphylococcus pseudintermedius (Staph. 
      pseudintermedius) were incubated with various fatty acid salts in distilled water 
      (DW) or UPSW and the number of bacteria was counted. Among the fatty acids, oleic 
      acid salt and linoleic acid (LA) salt reduced the number of these bacteria. Also, 
      UPSW enhanced the antibacterial effect of LA on Staph. spp. In spontaneously 
      developed itchy dermatitis in companion dogs, shampoo treatment with liquid soap 
      containing 10% LA in UPSW improved skin conditions. CONCLUSIONS: LA salt showed 
      antibacterial activity against Staph. spp. Treatment with soap containing LA with 
      UPSW reduced clinical conditions in dogs with dermatitis. SIGNIFICANCE AND IMPACT 
      OF THE STUDY: Because colonization of Staph. spp. on the skin exacerbates 
      dermatitis, the use of LA-containing soap in UPSW may reduce unpleasant clinical 
      symptoms of the skin.
CI  - (c) 2015 The Society for Applied Microbiology.
FAU - Jang, H
AU  - Jang H
AD  - Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications 
      and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
FAU - Makita, Y
AU  - Makita Y
AD  - R&D Center, MIURA Co. Ltd., Ehime, Japan.
FAU - Jung, K
AU  - Jung K
AD  - Laboratory of Comparative Animal Medicine, Division of Animal Life Science, 
      Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
FAU - Ishizaka, S
AU  - Ishizaka S
AD  - Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications 
      and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
FAU - Karasawa, K
AU  - Karasawa K
AD  - Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications 
      and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
FAU - Oida, K
AU  - Oida K
AD  - Laboratories of Veterinary Molecular Pathology and Therapeutics, Tokyo University 
      of Agriculture and Technology, Tokyo, Japan.
FAU - Takai, M
AU  - Takai M
AD  - R&D Center, MIURA Co. Ltd., Ehime, Japan.
FAU - Matsuda, H
AU  - Matsuda H
AD  - Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications 
      and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
AD  - Laboratories of Veterinary Molecular Pathology and Therapeutics, Tokyo University 
      of Agriculture and Technology, Tokyo, Japan.
FAU - Tanaka, A
AU  - Tanaka A
AD  - Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications 
      and System Engineering, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
AD  - Laboratory of Comparative Animal Medicine, Division of Animal Life Science, 
      Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Appl Microbiol
JT  - Journal of applied microbiology
JID - 9706280
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Soaps)
RN  - 059QF0KO0R (Water)
RN  - 2UMI9U37CP (Oleic Acid)
RN  - 9KJL21T0QJ (Linoleic Acid)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Dermatitis/drug therapy/microbiology/*veterinary
MH  - Dog Diseases/*drug therapy/microbiology
MH  - Dogs
MH  - Linoleic Acid/*administration & dosage
MH  - Oleic Acid
MH  - Skin/microbiology
MH  - Soaps
MH  - Staphylococcal Infections/drug therapy/microbiology/*veterinary
MH  - Staphylococcus/*drug effects/physiology
MH  - Water/*administration & dosage/chemistry
OTO - NOTNLM
OT  - Staphylococcus spp.
OT  - dermatitis
OT  - linoleic acid salt
OT  - skin
OT  - ultrapure soft water
EDAT- 2015/11/26 06:00
MHDA- 2016/11/08 06:00
CRDT- 2015/11/26 06:00
PHST- 2015/07/03 00:00 [received]
PHST- 2015/10/29 00:00 [revised]
PHST- 2015/11/17 00:00 [accepted]
PHST- 2015/11/26 06:00 [entrez]
PHST- 2015/11/26 06:00 [pubmed]
PHST- 2016/11/08 06:00 [medline]
AID - 10.1111/jam.13012 [doi]
PST - ppublish
SO  - J Appl Microbiol. 2016 Feb;120(2):280-8. doi: 10.1111/jam.13012.