PMID- 26607011
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20161126
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1858
IP  - 3
DP  - 2016 Mar
TI  - Giant MACPF/CDC pore forming toxins: A class of their own.
PG  - 475-86
LID - S0005-2736(15)00389-2 [pii]
LID - 10.1016/j.bbamem.2015.11.017 [doi]
AB  - Pore Forming Toxins (PFTs) represent a key mechanism for permitting the passage 
      of proteins and small molecules across the lipid membrane. These proteins are 
      typically produced as soluble monomers that self-assemble into ring-like 
      oligomeric structures on the membrane surface. Following such assembly PFTs 
      undergo a remarkable conformational change to insert into the lipid membrane. 
      While many different protein families have independently evolved such ability, 
      members of the Membrane Attack Complex PerForin/Cholesterol Dependent Cytolysin 
      (MACPF/CDC) superfamily form distinctive giant beta-barrel pores comprised of up to 
      50 monomers and up to 300A in diameter. In this review we focus on recent 
      advances in understanding the structure of these giant MACPF/CDC pores as well as 
      the underlying molecular mechanisms leading to their formation. Commonalities and 
      evolved variations of the pore forming mechanism across the superfamily are 
      discussed. This article is part of a Special Issue entitled: Pore-Forming Toxins 
      edited by Mauro Dalla Serra and Franco Gambale.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Reboul, Cyril F
AU  - Reboul CF
AD  - Department of Biochemistry and Molecular Biology, Monash University, Melbourne, 
      Australia; Australian Research Council Centre of Excellence in Advanced Molecular 
      Imaging, Monash University, Melbourne, Australia.
FAU - Whisstock, James C
AU  - Whisstock JC
AD  - Department of Biochemistry and Molecular Biology, Monash University, Melbourne, 
      Australia; Australian Research Council Centre of Excellence in Advanced Molecular 
      Imaging, Monash University, Melbourne, Australia.
FAU - Dunstone, Michelle A
AU  - Dunstone MA
AD  - Department of Biochemistry and Molecular Biology, Monash University, Melbourne, 
      Australia; Australian Research Council Centre of Excellence in Advanced Molecular 
      Imaging, Monash University, Melbourne, Australia; Department of Microbiology, 
      Monash University, Melbourne, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151126
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 126465-35-8 (Perforin)
SB  - IM
MH  - Animals
MH  - Cell Membrane/chemistry/*metabolism
MH  - *Evolution, Molecular
MH  - Humans
MH  - Perforin/chemistry/*classification/*metabolism
MH  - Protein Structure, Secondary
MH  - Structure-Activity Relationship
OTO - NOTNLM
OT  - CDC
OT  - MACPF
OT  - Membrane Attack Complex
OT  - Perforin
OT  - Pleurotolysin
OT  - Pore forming toxin
EDAT- 2015/11/27 06:00
MHDA- 2016/09/08 06:00
CRDT- 2015/11/27 06:00
PHST- 2015/07/01 00:00 [received]
PHST- 2015/11/16 00:00 [revised]
PHST- 2015/11/17 00:00 [accepted]
PHST- 2015/11/27 06:00 [entrez]
PHST- 2015/11/27 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
AID - S0005-2736(15)00389-2 [pii]
AID - 10.1016/j.bbamem.2015.11.017 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2016 Mar;1858(3):475-86. doi: 10.1016/j.bbamem.2015.11.017. 
      Epub 2015 Nov 26.