PMID- 26607405
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20170110
IS  - 1440-1789 (Electronic)
IS  - 0919-6544 (Linking)
VI  - 36
IP  - 2
DP  - 2016 Apr
TI  - Blood-brain barrier damage in vascular dementia.
PG  - 115-24
LID - 10.1111/neup.12262 [doi]
AB  - New findings on flow or drainage pathways of brain interstitial fluid and 
      cerebrospinal fluid have been made. The interstitial fluid flow has an effect on 
      the passage of blood-borne substances in the brain parenchyma, especially in 
      areas near blood-brain barrier (BBB)-free regions. Actually, blood-borne 
      substances can be transferred in areas with intact BBB function, such as the 
      hippocampus, the corpus callosum, periventricular areas, and medial portions of 
      the amygdala, presumably through leaky vessels in the subfornical organs or the 
      choroid plexus. Increasing evidence indicates that dysfunction of the BBB 
      function may play a significant role in the pathogenesis of vascular dementia. 
      Accordingly, we have examined which insults seen in patients suffering from 
      vascular dementia have an effect on the BBB using experimental animal models 
      exhibiting some phenotypes of vascular dementia. The BBB in the hippocampus was 
      clearly deteriorated in Mongolian gerbils exposed to acute ischemia followed by 
      reperfusion and also in stroke-prone spontaneously hypertensive rats (SHRSP) 
      showing hypertension. The BBB in the corpus callosum was clearly deteriorated in 
      Wistar rats with permanent ligation of the bilateral common carotid arteries 
      showing chronic hypoperfusion. The BBB in the hippocampus and the olfactory bulb 
      was mildly deteriorated in aged senescence accelerated prone mice (SAMP8) showing 
      cognitive dysfunction. The BBB in the hippocampus was mildly deteriorated in aged 
      animals with hydrocephalus. Mild endothelial damage was seen in hyperglycemic 
      db/db mice. In addition, mRNA expression of osteopontin, matrix 
      metalloproteinase-13 (MMP-13), and CD36 was increased in vessels showing BBB 
      damage in hypertensive SHRSP. As osteopontin, MMP-13 and CD36 are known to be 
      related to brain injury and amyloid beta accumulation or clearance, BBB damage 
      followed by increased gene expression of these molecules not only contributes to 
      the pathogenesis of vascular dementia, but also bridges the gap between vascular 
      dementia and Alzheimer's disease.
CI  - (c) 2015 Japanese Society of Neuropathology.
FAU - Ueno, Masaki
AU  - Ueno M
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Chiba, Yoichi
AU  - Chiba Y
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Matsumoto, Koichi
AU  - Matsumoto K
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Murakami, Ryuta
AU  - Murakami R
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Fujihara, Ryuji
AU  - Fujihara R
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Kawauchi, Machi
AU  - Kawauchi M
AD  - Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 
      Kagawa, Japan.
FAU - Miyanaka, Hiroshi
AU  - Miyanaka H
AD  - Life Science Research Center, Kagawa University, Kagawa, Japan.
FAU - Nakagawa, Toshitaka
AU  - Nakagawa T
AD  - Life Science Research Center, Kagawa University, Kagawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151126
PL  - Australia
TA  - Neuropathology
JT  - Neuropathology : official journal of the Japanese Society of Neuropathology
JID - 9606526
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*pathology
MH  - Dementia, Vascular/*pathology
MH  - Disease Models, Animal
MH  - Humans
OTO - NOTNLM
OT  - BBB
OT  - CD36
OT  - MMP-13
OT  - osteopontin
OT  - vascular dementia
EDAT- 2015/11/27 06:00
MHDA- 2017/01/10 06:00
CRDT- 2015/11/27 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/09/12 00:00 [revised]
PHST- 2015/09/13 00:00 [accepted]
PHST- 2015/11/27 06:00 [entrez]
PHST- 2015/11/27 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
AID - 10.1111/neup.12262 [doi]
PST - ppublish
SO  - Neuropathology. 2016 Apr;36(2):115-24. doi: 10.1111/neup.12262. Epub 2015 Nov 26.