PMID- 26607731
OWN - NLM
STAT- MEDLINE
DCOM- 20161109
LR  - 20240213
IS  - 1557-1904 (Electronic)
IS  - 1557-1890 (Print)
IS  - 1557-1890 (Linking)
VI  - 11
IP  - 1
DP  - 2016 Mar
TI  - Delta9-Tetrahydrocannabinol (Delta9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile 
      in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques.
PG  - 192-213
LID - 10.1007/s11481-015-9645-6 [doi]
AB  - Cannabinoid administration before and after simian immunodeficiency virus 
      (SIV)-inoculation ameliorated disease progression and decreased inflammation in 
      male rhesus macaques. Delta9-tetrahydrocannabinol (Delta9-THC) did not increase viral 
      load in brain tissue or produce additive neuropsychological impairment in 
      SIV-infected macaques. To determine if the neuroimmunomodulation of Delta9-THC 
      involved differential microRNA (miR) expression, miR expression in the striatum 
      of uninfected macaques receiving vehicle (VEH) or Delta9-THC (THC) and SIV-infected 
      macaques administered either vehicle (VEH/SIV) or Delta9-THC (THC/SIV) was profiled 
      using next generation deep sequencing. Among the 24 miRs that were differentially 
      expressed among the four groups, 16 miRs were modulated by THC in the presence of 
      SIV. These 16 miRs were classified into four categories and the biological 
      processes enriched by the target genes determined. Our results indicate that 
      Delta9-THC modulates miRs that regulate mRNAs of proteins involved in 1) neurotrophin 
      signaling, 2) MAPK signaling, and 3) cell cycle and immune response thus 
      promoting an overall neuroprotective environment in the striatum of SIV-infected 
      macaques. This is also reflected by increased Brain Derived Neurotrophic Factor 
      (BDNF) and decreased proinflammatory cytokine expression compared to the VEH/SIV 
      group. Whether Delta9-THC-mediated modulation of epigenetic mechanisms provides 
      neuroprotection in other regions of the brain and during chronic SIV-infection 
      remains to be determined.
FAU - Simon, Liz
AU  - Simon L
AD  - Department of Physiology, Alcohol and Drug Abuse Center of Excellence, Louisiana 
      State University Health Sciences, 1901 Perdido Street, Medical Education Building 
      7205, P7-3, New Orleans, LA, 70112, USA.
FAU - Song, Keijing
AU  - Song K
AD  - Department of Physiology, Louisiana State University Health Sciences Center, 1901 
      Perdido Street, New Orleans, LA, 70112, USA.
FAU - Vande Stouwe, Curtis
AU  - Vande Stouwe C
AD  - Department of Physiology, Louisiana State University Health Sciences Center, 1901 
      Perdido Street, New Orleans, LA, 70112, USA.
FAU - Hollenbach, Andrew
AU  - Hollenbach A
AD  - Department of Genetics, Louisiana State University Health Sciences Center, 1901 
      Perdido Street, New Orleans, LA, 70112, USA.
FAU - Amedee, Angela
AU  - Amedee A
AD  - Department of Microbiology, Immunology, & Parasitology; Alcohol and Drug Abuse 
      Center of Excellence, Louisiana State University Health Sciences Center, 1901 
      Perdido Street, New Orleans, LA, 70112, USA.
FAU - Mohan, Mahesh
AU  - Mohan M
AD  - Department of Comparative Pathology, Tulane National Primate Research Center, 
      18703 3 Rivers Rd, Covington, LA, 70433, USA.
FAU - Winsauer, Peter
AU  - Winsauer P
AD  - Department of Pharmacology; Alcohol and Drug Abuse Center of Excellence, 
      Louisiana State University Health Sciences Center, 1901 Perdido Street, New 
      Orleans, LA, 70112, USA.
FAU - Molina, Patricia
AU  - Molina P
AD  - Department of Physiology, Alcohol and Drug Abuse Center of Excellence, Louisiana 
      State University Health Sciences, 1901 Perdido Street, Medical Education Building 
      7205, P7-3, New Orleans, LA, 70112, USA. pmolin@lsuhsc.edu.
LA  - eng
GR  - P60 AA009803/AA/NIAAA NIH HHS/United States
GR  - P60AA09803/AA/NIAAA NIH HHS/United States
GR  - P51 RR000164/RR/NCRR NIH HHS/United States
GR  - P51 OD011104/OD/NIH HHS/United States
GR  - RR00164/RR/NCRR NIH HHS/United States
GR  - R01 DK083929/DK/NIDDK NIH HHS/United States
GR  - P30 GM106392/GM/NIGMS NIH HHS/United States
GR  - OD011104/OD/NIH HHS/United States
GR  - R01 DA030053/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151125
PL  - United States
TA  - J Neuroimmune Pharmacol
JT  - Journal of neuroimmune pharmacology : the official journal of the Society on 
      NeuroImmune Pharmacology
JID - 101256586
RN  - 0 (MicroRNAs)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Corpus Striatum/drug effects/*virology
MH  - Dronabinol/*pharmacology
MH  - Gene Expression/*drug effects
MH  - Macaca mulatta
MH  - Male
MH  - MicroRNAs/*biosynthesis
MH  - Neuroimmunomodulation/*drug effects/physiology
MH  - Polymerase Chain Reaction
MH  - Real-Time Polymerase Chain Reaction
MH  - Simian Acquired Immunodeficiency Syndrome/*virology
MH  - Simian Immunodeficiency Virus
MH  - Viral Load
PMC - PMC4773048
MID - NIHMS760003
OTO - NOTNLM
OT  - Cannabinoids
OT  - SIV
OT  - Striatum
OT  - miRNA
EDAT- 2015/11/27 06:00
MHDA- 2016/11/10 06:00
PMCR- 2017/03/01
CRDT- 2015/11/27 06:00
PHST- 2015/06/03 00:00 [received]
PHST- 2015/11/12 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2015/11/27 06:00 [entrez]
PHST- 2015/11/27 06:00 [pubmed]
PHST- 2016/11/10 06:00 [medline]
AID - 10.1007/s11481-015-9645-6 [pii]
AID - 10.1007/s11481-015-9645-6 [doi]
PST - ppublish
SO  - J Neuroimmune Pharmacol. 2016 Mar;11(1):192-213. doi: 10.1007/s11481-015-9645-6. 
      Epub 2015 Nov 25.