PMID- 26608186
OWN - NLM
STAT- MEDLINE
DCOM- 20160603
LR  - 20160203
IS  - 1522-1547 (Electronic)
IS  - 0193-1857 (Linking)
VI  - 310
IP  - 3
DP  - 2016 Feb 1
TI  - The role of liver progenitor cells during liver regeneration, fibrogenesis, and 
      carcinogenesis.
PG  - G143-54
LID - 10.1152/ajpgi.00215.2015 [doi]
AB  - The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to 
      increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, 
      and the metabolic syndrome has sparked interest in stem cell-like liver 
      progenitor cells (LPCs) as potential candidates for cell therapy and tissue 
      engineering, as an alternative approach to whole organ transplantation. However, 
      LPCs always proliferate in chronic liver diseases with a predisposition to 
      cancer; they have been suggested to play major roles in driving fibrosis, disease 
      progression, and may even represent tumor-initiating cells. Hence, a greater 
      understanding of the factors that govern their activation, communication with 
      other hepatic cell types, and bipotential differentiation as opposed to their 
      potential transformation is needed before their therapeutic potential can be 
      harnessed.
CI  - Copyright (c) 2016 the American Physiological Society.
FAU - Kohn-Gaone, Julia
AU  - Kohn-Gaone J
AD  - Curtin Health Innovation Research Institute, Curtin University, Perth Western 
      Australia, Australia;
FAU - Gogoi-Tiwari, Jully
AU  - Gogoi-Tiwari J
AD  - Curtin Health Innovation Research Institute, Curtin University, Perth Western 
      Australia, Australia;
FAU - Ramm, Grant A
AU  - Ramm GA
AD  - QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; 
      Faculty of Medicine and Biomedical Sciences, The University of Queensland, 
      Brisbane, Queensland, Australia;
FAU - Olynyk, John K
AU  - Olynyk JK
AD  - Curtin Health Innovation Research Institute, Curtin University, Perth Western 
      Australia, Australia; Fiona Stanley and Fremantle Hospitals, Western Australia, 
      Australia; School of Veterinary and Life Sciences, Murdoch University, Murdoch, 
      Western Australia, Australia; and.
FAU - Tirnitz-Parker, Janina E E
AU  - Tirnitz-Parker JE
AD  - Curtin Health Innovation Research Institute, Curtin University, Perth Western 
      Australia, Australia; School of Medicine and Pharmacology, University of Western 
      Australia, Fremantle Western Australia, Australia N.Tirnitz-Parker@curtin.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151125
PL  - United States
TA  - Am J Physiol Gastrointest Liver Physiol
JT  - American journal of physiology. Gastrointestinal and liver physiology
JID - 100901227
SB  - IM
MH  - Animals
MH  - Carcinogenesis/*pathology
MH  - Humans
MH  - Liver/*pathology
MH  - Liver Cirrhosis/*pathology
MH  - Liver Neoplasms/*pathology
MH  - *Liver Regeneration
MH  - *Stem Cells
OTO - NOTNLM
OT  - carcinogenesis
OT  - chronic liver disease
OT  - fibrosis
OT  - liver progenitor cells
OT  - liver regeneration
EDAT- 2015/11/27 06:00
MHDA- 2016/06/04 06:00
CRDT- 2015/11/27 06:00
PHST- 2015/06/30 00:00 [received]
PHST- 2015/11/19 00:00 [accepted]
PHST- 2015/11/27 06:00 [entrez]
PHST- 2015/11/27 06:00 [pubmed]
PHST- 2016/06/04 06:00 [medline]
AID - ajpgi.00215.2015 [pii]
AID - 10.1152/ajpgi.00215.2015 [doi]
PST - ppublish
SO  - Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G143-54. doi: 
      10.1152/ajpgi.00215.2015. Epub 2015 Nov 25.