PMID- 26608718
OWN - NLM
STAT- MEDLINE
DCOM- 20161221
LR  - 20180816
IS  - 1532-2785 (Electronic)
IS  - 0143-4179 (Linking)
VI  - 56
DP  - 2016 Apr
TI  - Effect of curcumin on serum brain-derived neurotrophic factor levels in women 
      with premenstrual syndrome: A randomized, double-blind, placebo-controlled trial.
PG  - 25-31
LID - S0143-4179(15)00118-3 [pii]
LID - 10.1016/j.npep.2015.11.003 [doi]
AB  - Premenstrual syndrome (PMS) is a variety of physical, mental, and behavioral 
      symptoms that start during the late luteal phase of the menstrual cycle, and the 
      symptoms disappear after the onset of menses. Serum brain-derived neurotrophic 
      factor (BDNF) levels during luteal phase in women associated with PMS have more 
      alterations than women not suffering from PMS. In this regard, altered luteal 
      BDNF levels in women with PMS might play a role in a set of psychological and 
      somatic symptoms of the PMS. Studies of last decade revealed neuroprotective 
      effects of curcumin and its ability to increase BDNF levels. In the present 
      study, we evaluated the effect of curcumin on serum BDNF level and PMS symptoms 
      severity in women with PMS. Present study is a Randomized, Double-Blinded, 
      Placebo-Controlled Clinical Trial. Curcumin treatment was given for three 
      successive menstrual cycles and each cycle ran 10 days. After having identified 
      persons with PMS, participants were randomly allocated into placebo (n=35) and 
      curcumin (n=35) groups. Each sample in placebo and curcumin groups received two 
      capsules daily for seven days before menstruation and for three days after 
      menstruation for three successive menstrual cycles. Participants noted the 
      severity of the symptoms mentioned in the daily record questionnaire. Self-report 
      was used to determine menstrual cycle phase of participants. At the fourth day of 
      each menstrual cycle venous blood samples were collected for BDNF measurement by 
      ELISA method. Before intervention, BDNF levels and mean scores of PMS symptoms 
      (mood, behavioral and physical symptoms) between two groups showed no significant 
      differences. But in curcumin group first, second and third cycles after 
      interventions BDNF levels were significantly higher and mean scores of PMS 
      symptoms were significantly less than placebo group. Based on our results part of 
      these beneficial effects of curcumin may be mediated through enhancing serum BDNF 
      levels in women with PMS.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Fanaei, Hamed
AU  - Fanaei H
AD  - Pregnancy Health Research Center, Zahedan University of Medical Sciences, 
      Zahedan, Iran; Department of Physiology, School of Medicine, Zahedan University 
      of Medical Sciences, Zahedan, Iran.
FAU - Khayat, Samira
AU  - Khayat S
AD  - Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of 
      Reproductive Health, School of Nursing and Midwifery, Tehran University of 
      Medical Sciences, Tehran, Iran. Electronic address: khayatmsc@yahoo.com.
FAU - Kasaeian, Amir
AU  - Kasaeian A
AD  - Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran 
      University of Medical Sciences, Tehran, Iran; Non-communicable Diseases Research 
      Center, Endocrinology and Metabolism Population Sciences Institute, Tehran 
      University of Medical Sciences, Tehran, Iran; Department of Epidemiology and 
      Biostatistics, School of Public Health, Tehran University of Medical Sciences, 
      Tehran, Iran.
FAU - Javadimehr, Mani
AU  - Javadimehr M
AD  - School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20151111
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Curcumin/*administration & dosage
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Premenstrual Syndrome/*blood/*prevention & control
MH  - Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Curcumin
OT  - Premenstrual syndrome
EDAT- 2015/11/27 06:00
MHDA- 2016/12/22 06:00
CRDT- 2015/11/27 06:00
PHST- 2015/04/10 00:00 [received]
PHST- 2015/11/10 00:00 [revised]
PHST- 2015/11/10 00:00 [accepted]
PHST- 2015/11/27 06:00 [entrez]
PHST- 2015/11/27 06:00 [pubmed]
PHST- 2016/12/22 06:00 [medline]
AID - S0143-4179(15)00118-3 [pii]
AID - 10.1016/j.npep.2015.11.003 [doi]
PST - ppublish
SO  - Neuropeptides. 2016 Apr;56:25-31. doi: 10.1016/j.npep.2015.11.003. Epub 2015 Nov 
      11.