PMID- 26611553
OWN - NLM
STAT- MEDLINE
DCOM- 20160912
LR  - 20151127
IS  - 1558-3163 (Electronic)
IS  - 0889-857X (Linking)
VI  - 42
IP  - 1
DP  - 2016 Feb
TI  - Corticosteroids in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
PG  - 91-101, viii
LID - S0889-857X(15)00074-5 [pii]
LID - 10.1016/j.rdc.2015.08.010 [doi]
AB  - Glucocorticoids (GCs) have been the cornerstone of antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV) therapy since their advent in the 1950s. 
      There is considerable variation in their use, both with respect to dose and 
      duration. Given considerable treatment-related morbidity and mortality, refining 
      the role of GCs is becoming increasingly important. This article discusses the 
      current role of GCs in various phases of AAV treatment, including remission 
      induction, maintenance therapy, treatment of relapses, and the use of local GCs. 
      It discusses current controversies relating to GC use as well as research efforts 
      that seek to reduce GC toxicity in AAV.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Keller, Sarah F
AU  - Keller SF
AD  - Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, 
      MA 02114, USA.
FAU - Miloslavsky, Eli M
AU  - Miloslavsky EM
AD  - Division of Rheumatology, Department of Medicine, Yawkey Center for Outpatient 
      Care, Massachusetts General Hospital, Harvard Medical School, Suite 2C, Boston, 
      MA 02114, USA. Electronic address: emiloslavsky@mgh.harvard.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151024
PL  - United States
TA  - Rheum Dis Clin North Am
JT  - Rheumatic diseases clinics of North America
JID - 8708093
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Administration, Intravenous
MH  - Administration, Oral
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy
MH  - Glucocorticoids/*therapeutic use
MH  - Granulomatosis with Polyangiitis/*drug therapy
MH  - Humans
MH  - Maintenance Chemotherapy
MH  - Microscopic Polyangiitis/*drug therapy
MH  - Remission Induction
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Glucocorticoids
OT  - Granulomatosis with polyangiitis
OT  - Microscopic polyangiitis
EDAT- 2015/11/28 06:00
MHDA- 2016/09/13 06:00
CRDT- 2015/11/28 06:00
PHST- 2015/11/28 06:00 [entrez]
PHST- 2015/11/28 06:00 [pubmed]
PHST- 2016/09/13 06:00 [medline]
AID - S0889-857X(15)00074-5 [pii]
AID - 10.1016/j.rdc.2015.08.010 [doi]
PST - ppublish
SO  - Rheum Dis Clin North Am. 2016 Feb;42(1):91-101, viii. doi: 
      10.1016/j.rdc.2015.08.010. Epub 2015 Oct 24.