PMID- 2661207
OWN - NLM
STAT- MEDLINE
DCOM- 19890802
LR  - 20220318
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 125
IP  - 1
DP  - 1989 Jul
TI  - Multiple cytokines stimulate hepatic lipid synthesis in vivo.
PG  - 267-74
AB  - We have previously shown that administration of tumor necrosis factor-alpha (TNF 
      alpha) to intact rats results in an acute (within 60-120 min) stimulation of 
      hepatic fatty acid synthesis, which persists for an extended period. Hepatic 
      cholesterol synthesis is also stimulated by 16-17 h after TNF alpha treatment. We 
      now demonstrate, using intact mice, that stimulation of hepatic lipid synthesis 
      is not solely the property of the cytokine TNF alpha. Incorporation of 3H2O into 
      fatty acids in the liver was increased 60-120 min and 16-17 h after the 
      administration of TNF beta, interleukin-1 (IL-1), and interferon-alpha (IFN 
      alpha). TNF alpha, IL-1, and IFN alpha all rapidly stimulate hepatic fatty acid 
      synthesis (within 0-30 min), with the peak occurring at 60-120 min. The 
      half-maximal doses of TNF alpha (200 ng) and IL-1 (20 ng) that stimulate hepatic 
      fatty acid synthesis are similar to those that induce fever, a well recognized 
      biological effect of these cytokines. Additionally, hepatic cholesterol synthesis 
      was increased 16-17 h after TNF beta, IL-1, and IFN gamma treatment. The present 
      study demonstrates that multiple cytokines from different cell types which act 
      through different receptors can stimulate hepatic fatty acid and cholesterol 
      synthesis. Previous studies have shown that multiple cytokines can inhibit the 
      synthesis and storage of fat in cultured adipose cells. Taken together, these 
      data indicate that multiple signals to perturb lipid metabolism may be produced 
      as a consequence of an immunological or inflammatory response.
FAU - Feingold, K R
AU  - Feingold KR
AD  - Department of Medicine, University of California, San Francisco.
FAU - Soued, M
AU  - Soued M
FAU - Serio, M K
AU  - Serio MK
FAU - Moser, A H
AU  - Moser AH
FAU - Dinarello, C A
AU  - Dinarello CA
FAU - Grunfeld, C
AU  - Grunfeld C
LA  - eng
GR  - AI-15614/AI/NIAID NIH HHS/United States
GR  - AM-37102/AM/NIADDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Biological Factors)
RN  - 0 (Cytokines)
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - Biological Factors/administration & dosage/*pharmacology
MH  - Cytokines
MH  - Dose-Response Relationship, Drug
MH  - Lipids/*biosynthesis
MH  - Liver/*metabolism
MH  - Male
MH  - Mice
MH  - Stimulation, Chemical
MH  - Time Factors
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 10.1210/endo-125-1-267 [doi]
PST - ppublish
SO  - Endocrinology. 1989 Jul;125(1):267-74. doi: 10.1210/endo-125-1-267.