PMID- 26613251
OWN - NLM
STAT- MEDLINE
DCOM- 20160817
LR  - 20211203
IS  - 1750-3841 (Electronic)
IS  - 0022-1147 (Linking)
VI  - 81
IP  - 1
DP  - 2016 Jan
TI  - Resveratrol Regulates Activated Hepatic Stellate Cells by Modulating NF-kappaB and 
      the PI3K/Akt Signaling Pathway.
PG  - H240-5
LID - 10.1111/1750-3841.13157 [doi]
AB  - In the present study, we investigated whether resveratrol could suppress the 
      hepatic fibrogenesis in activated hepatic stellate cells. The immortalized rat 
      hepatic stellate cells, t-HSC/Cl-6, were treated with resveratrol 1 h prior to 
      lipopolysaccharide (LPS, 1 mug/mL). Resveratrol decreased t-HSC/Cl-6 cell 
      viability at much lower concentrations within 24 h. Resveratrol pretreatment also 
      decreased the LPS-induced protein expression of alpha-SMA and collagen I. In 
      addition, resveratrol significantly reduced the protein expression of Toll-like 
      receptor 4 (TLR4) and myeloid differentiation primary response gene 88 (MyD88), 
      and the expression of phosphorylated phosphatidylinositol 3-kinase (PI3K) and 
      phosphorylated serine/threonine kinase B (Akt). Moreover, resveratrol markedly 
      blocked the translocation of nuclear factor (NF)-kappaB in LPS-activated HSCs. 
      Furthermore, resveratrol inhibited HSCs activation through stimulating LXRbeta, but 
      did not influence LXRalpha. Overall, we conclude that the antifibrotic effect of 
      resveratrol is the result of blocking NF-kappaB activation and PI3K/Akt 
      phosphorylation, which inhibits HSC activation to obstruct liver fibrosis. Thus, 
      resveratrol may be a natural agent for preventing hepatic fibrosis.
CI  - (c) 2015 Institute of Food Technologists(R)
FAU - Zhang, De-Quan
AU  - Zhang DQ
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Sun, Peng
AU  - Sun P
AD  - Dept. of Pharmacy, Yanbian Univ. Hospital, Yanji, 133000, Jilin Province, China.
FAU - Jin, Quan
AU  - Jin Q
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Li, Xia
AU  - Li X
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Zhang, Yu-Jing
AU  - Zhang YJ
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Wu, Yan-Ling
AU  - Wu YL
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Nan, Ji-Xing
AU  - Nan JX
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
FAU - Lian, Li-Hua
AU  - Lian LH
AD  - Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules, 
      Ministry of Education, College of Pharmacy, Yanbian Univ, Yanji, 133002, Jilin 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151127
PL  - United States
TA  - J Food Sci
JT  - Journal of food science
JID - 0014052
RN  - 0 (Actins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Myd88 protein, rat)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (Stilbenes)
RN  - 0 (Tlr4 protein, rat)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (smooth muscle actin, rat)
RN  - 9007-34-5 (Collagen)
RN  - EC 2.7.1.137 (Phosphatidylinositol 3-Kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Collagen/metabolism
MH  - Hepatic Stellate Cells/*drug effects/metabolism/pathology
MH  - Lipopolysaccharides
MH  - Liver/*drug effects/metabolism/pathology
MH  - Liver Cirrhosis/*metabolism/pathology/prevention & control
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - NF-kappa B/*metabolism
MH  - Phosphatidylinositol 3-Kinase/*metabolism
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Phosphorylation
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Rats
MH  - Resveratrol
MH  - Signal Transduction
MH  - Stilbenes/*pharmacology/therapeutic use
MH  - Toll-Like Receptor 4/metabolism
OTO - NOTNLM
OT  - Akt
OT  - NF-kappaB
OT  - PI3K
OT  - hepatic stellate cell
OT  - resveratrol
EDAT- 2015/11/28 06:00
MHDA- 2016/08/18 06:00
CRDT- 2015/11/28 06:00
PHST- 2015/07/08 00:00 [received]
PHST- 2015/10/18 00:00 [accepted]
PHST- 2015/11/28 06:00 [entrez]
PHST- 2015/11/28 06:00 [pubmed]
PHST- 2016/08/18 06:00 [medline]
AID - 10.1111/1750-3841.13157 [doi]
PST - ppublish
SO  - J Food Sci. 2016 Jan;81(1):H240-5. doi: 10.1111/1750-3841.13157. Epub 2015 Nov 
      27.