PMID- 26614266
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20180609
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 23
IP  - 6
DP  - 2016 Jun
TI  - Altered Maternal Plasma Glycogen Phosphorylase Isoenzyme BB as a Biomarker for 
      Preeclampsia and Small for Gestational Age.
PG  - 738-47
LID - 10.1177/1933719115616495 [doi]
AB  - OBJECTIVES: To investigate whether maternal plasma glycogen phosphorylase BB 
      (GPBB) levels were altered in early pregnancy and/or at the time of diagnosis of 
      disease in preeclampsia (term and preterm <37 weeks' gestation) or small for 
      gestational age (SGA). METHODS: We conducted 6 nested case-control studies within 
      the Screening of Pregnancy Endpoint (SCOPE) Ireland cohort. Blood samples from 
      women with preeclampsia or SGA were analyzed both from the time of disease 
      presentation and at 15 and 20 weeks' gestation. These were compared with control 
      samples obtained from SCOPE women with healthy uncomplicated pregnancies matched 
      for age, ethnicity, parity, body mass index, and gestational age. Glycogen 
      phosphorylase BB levels were measured using the Diacordon GPBB enzyme-linked 
      immunosorbent assay (Diagenics, Germany). RESULTS: Glycogen phosphorylase BB 
      levels were higher in women with preeclampsia compared with controls at the time 
      of disease (term preeclampsia median [interquartile range (IQR)]: 22.2 
      [15.1-39.8] ng/mL vs 16.9 [10.4-19.1] ng/mL; P = .04; N = 14 and preterm 
      preeclampsia median [IQR]: 23.1 [11.2-30.9] ng/mL vs 17.2 [9.8-19.1] ng/mL; P = 
      .04; N = 11) and at 20 weeks' gestation (median [IQR]: 23.0 [15.6-31.4] ng/mL vs 
      17.0 [13.4-23.6] ng/mL; N = 39; P = .04). Glycogen phosphorylase BB levels were 
      also significantly higher in women with SGA compared with normal controls at the 
      time of disease detection (median [IQR]: 22.7 [12.6-25.5] ng/mL vs 17.0 
      [9.8-18.0] ng/mL; N = 23; P = .03) but significantly less than controls at 15 
      weeks' gestation prior to disease detection (median [IQR]: 16.0 [12.1-23.2] ng/mL 
      vs 22.2 [17.0-28.9] ng/mL; N = 25; P = .02). CONCLUSION: Glycogen phosphorylase 
      BB alone has modest predictive abilities for the development of preeclampsia or 
      SGA. Further research may examine its use in combination with other markers.
CI  - (c) The Author(s) 2015.
FAU - McCarthy, Fergus P
AU  - McCarthy FP
AD  - Department of Obstetrics and Gynaecology, The Irish Centre for Fetal and Neonatal 
      Translational Research (INFANT), University College Cork, Cork, Ireland Division 
      of Women's Health, Women's Health Academic Centre, King's Health Partners, 
      London, United Kingdom fergus.mccarthy@ucc.ie.
FAU - Doyle, Aisling
AU  - Doyle A
AD  - Department of Obstetrics and Gynaecology, The Irish Centre for Fetal and Neonatal 
      Translational Research (INFANT), University College Cork, Cork, Ireland.
FAU - Khashan, Ali S
AU  - Khashan AS
AD  - Department of Obstetrics and Gynaecology, The Irish Centre for Fetal and Neonatal 
      Translational Research (INFANT), University College Cork, Cork, Ireland 
      Department of Epidemiology and Public Health, University College Cork, Cork, 
      Ireland.
FAU - Kenny, Louise C
AU  - Kenny LC
AD  - Department of Obstetrics and Gynaecology, The Irish Centre for Fetal and Neonatal 
      Translational Research (INFANT), University College Cork, Cork, Ireland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151126
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Biomarkers)
RN  - 0 (Isoenzymes)
RN  - EC 2.4.1.- (Glycogen Phosphorylase)
RN  - EC 2.4.1.- (glycogen phosphorylase BB, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Growth Retardation/*blood/*diagnostic imaging
MH  - Gestational Age
MH  - Glycogen Phosphorylase/*blood
MH  - Humans
MH  - Hypertension, Pregnancy-Induced/blood/diagnosis
MH  - Infant, Small for Gestational Age
MH  - Ireland
MH  - Isoenzymes/blood
MH  - Pre-Eclampsia/*blood/*diagnosis
MH  - Pregnancy
MH  - Pregnancy Trimesters
MH  - Sensitivity and Specificity
MH  - Young Adult
OTO - NOTNLM
OT  - biomarker
OT  - glycogen phosphorylase isoenzyme BB
OT  - preeclampsia
OT  - small for gestational age
EDAT- 2015/11/29 06:00
MHDA- 2017/10/11 06:00
CRDT- 2015/11/29 06:00
PHST- 2015/11/29 06:00 [entrez]
PHST- 2015/11/29 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
AID - 1933719115616495 [pii]
AID - 10.1177/1933719115616495 [doi]
PST - ppublish
SO  - Reprod Sci. 2016 Jun;23(6):738-47. doi: 10.1177/1933719115616495. Epub 2015 Nov 
      26.