PMID- 26614534
OWN - NLM
STAT- MEDLINE
DCOM- 20160712
LR  - 20181202
IS  - 1399-5618 (Electronic)
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 17
IP  - 8
DP  - 2015 Dec
TI  - Social rhythm disrupting events increase the risk of recurrence among individuals 
      with bipolar disorder.
PG  - 869-79
LID - 10.1111/bdi.12351 [doi]
AB  - OBJECTIVES: As outlined in the social zeitgeber hypothesis, social rhythm 
      disrupting (SRD) life events begin a cascade of social and biological rhythm 
      disruption that may lead to the onset of affective episodes in those vulnerable 
      to bipolar disorder. Thus, the study of SRD events is particularly important in 
      individuals with this chronic condition. The purpose of the current study was to 
      evaluate (i) the extent to which SRD life events increased the risk of recurrence 
      of a bipolar mood episode, and (ii) whether the social rhythm disruption 
      associated with the event conferred an increased risk of recurrence, after 
      accounting for the level of threat associated with the life event. METHODS: We 
      examined the effect of SRD events on recurrence during preventative treatment in 
      a sample of 118 patients with bipolar disorder who achieved remission from an 
      acute episode after receiving psychotherapy and pharmacotherapy. Life events were 
      measured with the Bedford College Life Events and Difficulty Schedule and were 
      rated for degree of SRD and threat. RESULTS: Time-dependent Cox proportional 
      hazards models showed that having a higher SRD rating was significantly 
      associated with an increased risk of recurrence, even when accounting for the 
      threat effect of a life event and psychosocial treatment (hazard ratio = 1.33, 
      95% confidence interval: 1.04-1.70, p = 0.023). However, this finding fell below 
      conventional levels of statistical significance when accounting for other 
      covariates. CONCLUSIONS: Our findings lend partial support to the social 
      zeitgeber hypothesis.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Levenson, Jessica C
AU  - Levenson JC
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA.
FAU - Wallace, Meredith L
AU  - Wallace ML
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA.
FAU - Anderson, Barbara P
AU  - Anderson BP
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Kupfer, David J
AU  - Kupfer DJ
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA.
FAU - Frank, Ellen
AU  - Frank E
AD  - Department of Psychiatry, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA, USA.
AD  - Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
LA  - eng
GR  - R01 MH029618/MH/NIMH NIH HHS/United States
GR  - MH29618/MH/NIMH NIH HHS/United States
GR  - K01MH096944/MH/NIMH NIH HHS/United States
GR  - T32 HL082610/HL/NHLBI NIH HHS/United States
GR  - HL082610/HL/NHLBI NIH HHS/United States
GR  - R37 MH029618/MH/NIMH NIH HHS/United States
GR  - K01 MH096944/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151128
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*diagnosis/psychology/therapy
MH  - Depression/*diagnosis
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - *Life Change Events
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Psychotropic Drugs/therapeutic use
MH  - Recurrence
MH  - Risk Assessment/methods
MH  - Socioenvironmental Therapy/methods
MH  - Sociological Factors
MH  - Statistics as Topic
PMC - PMC4702482
MID - NIHMS744776
OTO - NOTNLM
OT  - life events
OT  - mood
OT  - recurrence
OT  - social rhythms
OT  - social zeitgeber
OT  - threat
EDAT- 2015/11/29 06:00
MHDA- 2016/07/13 06:00
PMCR- 2016/12/01
CRDT- 2015/11/29 06:00
PHST- 2015/01/21 00:00 [received]
PHST- 2015/09/16 00:00 [revised]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2015/11/29 06:00 [entrez]
PHST- 2015/11/29 06:00 [pubmed]
PHST- 2016/07/13 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.1111/bdi.12351 [doi]
PST - ppublish
SO  - Bipolar Disord. 2015 Dec;17(8):869-79. doi: 10.1111/bdi.12351. Epub 2015 Nov 28.