PMID- 26615579
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20220331
IS  - 1532-2688 (Electronic)
IS  - 1059-1311 (Linking)
VI  - 34
DP  - 2016 Jan
TI  - Color density spectral array of bilateral bispectral index system: 
      Electroencephalographic correlate in comatose patients with nonconvulsive status 
      epilepticus.
PG  - 18-25
LID - S1059-1311(15)00264-2 [pii]
LID - 10.1016/j.seizure.2015.11.001 [doi]
AB  - PURPOSE: to describe the characteristics of the color density spectral array 
      (CDSA) of bilateral bispectral index (b-BIS) monitoring system in patients with 
      comatose nonconvulsive status epilepticus (NCSE). We hypothesized that CDSA could 
      be helpful for monitoring NCSE in critically subjects if continuous EEG (cEEG) is 
      not available. METHODS: we retrospectively analyzed comatose patients admitted to 
      our neurological intensive care unit (NICU) from 2011 to 2014 with a diagnosis of 
      definitive NCSE that underwent b-BIS monitoring for at least 24h to guide 
      anesthetic sedation. Clinical, electroencephalography and neuroimaging findings 
      were analyzed. Moreover, all parameters from the b-BIS data including the CDSA 
      were reviewed during periods of NCSE (NCSE pattern) and profound sedation 
      (sedation pattern). RESULTS: 15 NCSE patients were included. The delay from the 
      diagnosis of NCSE to the onset of b-BIS monitoring was 8 (0.5-31)h and total time 
      of b-BIS monitoring 7.8+/-6.5 days. CDSA during NCSE pattern was characterized by 
      continuous or intermittent red and dark red tones, spectral edge frequency (SEF) 
      in the delta-theta range, with or without asymmetry and BIS number trend with 
      significant variability. In contrast, CDSA during sedation revealed predominance 
      of orange, yellow, green and occasionally blue tones, SEF in the alpha-beta 
      range, absence of asymmetry and stability of BIS number. CONCLUSIONS: b-BIS 
      monitoring system and, in particular, CDSA used by nonexpert NICU personnel may 
      be helpful to follow-up episodes of NCSE, to detect recurrences of nonconvulsive 
      seizures (NCSzs), and to monitor profound anesthetic therapy in comatose patients 
      when cEEG is not available.
CI  - Copyright (c) 2015 British Epilepsy Association. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Hernandez-Hernandez, Miguel A
AU  - Hernandez-Hernandez MA
AD  - Department of Intensive Medicine, Marques de Valdecilla University Hospital, 
      Santander, Cantabria, Spain; Biomedical Research Institute (IDIVAL), Santander, 
      Spain. Electronic address: mahernandez@humv.es.
FAU - Fernandez-Torre, Jose L
AU  - Fernandez-Torre JL
AD  - Department of Clinical Neurophysiology, Marques de Valdecilla University 
      Hospital, Santander, Cantabria, Spain; Biomedical Research Institute (IDIVAL), 
      Santander, Spain; Department of Physiology and Pharmacology, University of 
      Cantabria (UNICAN), Santander, Cantabria, Spain.
LA  - eng
PT  - Journal Article
DEP - 20151110
PL  - England
TA  - Seizure
JT  - Seizure
JID - 9306979
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Coma/*complications/physiopathology
MH  - *Consciousness Monitors
MH  - Electroencephalography/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Status Epilepticus/*diagnosis/physiopathology
OTO - NOTNLM
OT  - Bispectral index
OT  - Color density spectral array
OT  - Neurointensive care unit
OT  - Nonconvulsive status epilepticus
OT  - Quantitative EEG
OT  - Seizure
EDAT- 2015/11/30 06:00
MHDA- 2016/12/30 06:00
CRDT- 2015/11/30 06:00
PHST- 2015/07/27 00:00 [received]
PHST- 2015/10/05 00:00 [revised]
PHST- 2015/11/03 00:00 [accepted]
PHST- 2015/11/30 06:00 [entrez]
PHST- 2015/11/30 06:00 [pubmed]
PHST- 2016/12/30 06:00 [medline]
AID - S1059-1311(15)00264-2 [pii]
AID - 10.1016/j.seizure.2015.11.001 [doi]
PST - ppublish
SO  - Seizure. 2016 Jan;34:18-25. doi: 10.1016/j.seizure.2015.11.001. Epub 2015 Nov 10.