PMID- 26615652
OWN - NLM
STAT- MEDLINE
DCOM- 20151224
LR  - 20151130
IS  - 1210-7778 (Print)
IS  - 1210-7778 (Linking)
VI  - 23
IP  - 3
DP  - 2015 Sep
TI  - PERSISTENT ORGANOCHLORINE POLLUTANTS IN OBESE WOMEN AFTER DIET INDUCED WEIGHT 
      LOSS: FIVE YEARS FOLLOW UP STUDY.
PG  - 214-7
AB  - AIM: Persistent organochlorine pollutants (POPs) from the environment are still 
      bioaccumulating in human tissues. The aim of our study was to analyze the 
      development of plasma POPs levels in obese women in relationship with their 
      weight loss success in five year follow-up study. METHODS: 20 obese women aged 
      25-73 years were studied just before and after having completed a 3 month 
      controlled low calorie diet (LCD) intervention (5 MJ daily), and again after 6 
      and 60 months since the beginning of the study. Body weight and plasma levels of 
      7 POPs were measured: polychlorinated biphenyls (PCB) 153, 138, 180; 
      2,2-bis(4-chlorophenyl)-1,1,1-trichloroethylene (p,p'-DDE); 
      2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), hexachlorocyclobenzene 
      (HCB), hexachlorocyclohexane beta (HCH beta). RESULTS: Data shows that after 3 months 
      of a completely controlled restrictive diet regimen, the weight loss was 
      associated with an increase in POP plasma levels. However, after a five year 
      follow-up, there were no differences in POPs plasma levels between those who kept 
      losing weight or maintained the initial weight (WL/M) and the group of weight 
      gainers (WG), except for HCB where the WG had a significantly higher level (p < 
      0.05). CONCLUSIONS: These results suggest that contrary to the long-term weight 
      gain, the long-term weight loss or weight maintenance caused by diet restriction 
      is associated with lower plasma levels of HCB.
FAU - Mullerova, Dana
AU  - Mullerova D
FAU - Matejkova, Dagmar
AU  - Matejkova D
FAU - Dvorakova, Jana
AU  - Dvorakova J
FAU - Muller, Ludek
AU  - Muller L
FAU - Rosmus, Jan
AU  - Rosmus J
FAU - Kovarova, Katerina
AU  - Kovarova K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Czech Republic
TA  - Cent Eur J Public Health
JT  - Central European journal of public health
JID - 9417324
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Environmental Exposure/*analysis
MH  - Environmental Pollutants/*blood/pharmacokinetics
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood/pharmacokinetics
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Weight Loss/*physiology
EDAT- 2015/12/01 06:00
MHDA- 2015/12/25 06:00
CRDT- 2015/12/01 06:00
PHST- 2015/12/01 06:00 [entrez]
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2015/12/25 06:00 [medline]
AID - 10.21101/cejph.a4100 [doi]
PST - ppublish
SO  - Cent Eur J Public Health. 2015 Sep;23(3):214-7. doi: 10.21101/cejph.a4100.