PMID- 26616138
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20181202
IS  - 1941-2444 (Electronic)
IS  - 0148-6071 (Linking)
VI  - 41
IP  - 5
DP  - 2017 Jul
TI  - Fecal Transplantation Successfully Treats Recurrent D-Lactic Acidosis in a Child 
      With Short Bowel Syndrome.
PG  - 896-897
LID - 10.1177/0148607115619931 [doi]
AB  - D-lactic acidosis can occur in patients with short bowel syndrome (SBS) when 
      excessive malabsorbed carbohydrate (CHO) enters the colon and is metabolized by 
      colonic bacteria to D-lactate. D-lactate can be absorbed systemically, and 
      increased serum levels are associated with central nervous system toxicity 
      manifested by confusion, ataxia, and slurred speech. Current therapy, usually 
      directed toward suppressing intestinal bacterial overgrowth and limiting ingested 
      CHO, is not always successful. Fecal transplantation, the infusion of donor feces 
      into a recipient's intestinal tract, has been used for decades to treat recurrent 
      Clostridium difficile infection, and case reports document its use in the 
      successful treatment of constipation, diarrhea, and abdominal pain. The exact 
      mechanism of action is unknown, but it is surmised that the alteration of the 
      intestinal microbiome, as well as the reintroduction of potential beneficial 
      microbes, helps mediate disease. Here we present the case of a child with SBS and 
      recurrent, debilitating D-lactic acidosis, which was successfully treated with 
      fecal transplantation.
FAU - Davidovics, Zev H
AU  - Davidovics ZH
AD  - 1 Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's 
      Medical Center, Hartford, Connecticut, USA.
FAU - Vance, Katherine
AU  - Vance K
AD  - 1 Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's 
      Medical Center, Hartford, Connecticut, USA.
FAU - Etienne, Nancy
AU  - Etienne N
AD  - 1 Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's 
      Medical Center, Hartford, Connecticut, USA.
FAU - Hyams, Jeffrey S
AU  - Hyams JS
AD  - 1 Division of Digestive Diseases, Hepatology & Nutrition, Connecticut Children's 
      Medical Center, Hartford, Connecticut, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20151129
PL  - United States
TA  - JPEN J Parenter Enteral Nutr
JT  - JPEN. Journal of parenteral and enteral nutrition
JID - 7804134
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Acidosis, Lactic/complications/*therapy
MH  - Adolescent
MH  - *Fecal Microbiota Transplantation
MH  - Feces/chemistry/microbiology
MH  - Humans
MH  - Intestinal Mucosa/metabolism
MH  - Intestines/microbiology
MH  - Lactic Acid/blood
MH  - Male
MH  - Recurrence
MH  - Short Bowel Syndrome/complications/*therapy
OTO - NOTNLM
OT  - enteral formulas
OT  - gastroenterology
OT  - nutrition
OT  - research and diseases
OT  - short bowel syndrome
EDAT- 2015/12/01 06:00
MHDA- 2018/05/08 06:00
CRDT- 2015/12/01 06:00
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2015/12/01 06:00 [entrez]
AID - 0148607115619931 [pii]
AID - 10.1177/0148607115619931 [doi]
PST - ppublish
SO  - JPEN J Parenter Enteral Nutr. 2017 Jul;41(5):896-897. doi: 
      10.1177/0148607115619931. Epub 2015 Nov 29.