PMID- 26617157
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1618-0402 (Electronic)
IS  - 0940-9602 (Linking)
VI  - 204
DP  - 2016 Mar
TI  - Morphological differences in adipose tissue and changes in BDNF/Trkb expression 
      in brain and gut of a diet induced obese zebrafish model.
PG  - 36-44
LID - S0940-9602(15)00145-4 [pii]
LID - 10.1016/j.aanat.2015.11.003 [doi]
AB  - Obesity is a multifactorial disease generated by an alteration in balance between 
      energy intake and expenditure, also dependent on genetic and non-genetic factors. 
      Moreover, various nuclei of the hypothalamus receive and process peripheral 
      stimuli from the gastrointestinal tract, controlling food intake and therefore 
      energy balance. Among anorexigenic molecules, brain-derived neurotrophic factor 
      (BDNF) acts through the tyrosine-kinase receptor TrkB. Numerous data demonstrate 
      that the BDNF/TrkB system has a fundamental role in the control of food intake 
      and body weight. Quantitative PCR and immunohistochemistry for both BDNF and TrkB 
      were used to determine changes in levels in the brain and gastro-intestinal tract 
      of an experimental zebrafish model of diet-induced obesity. Overfed animals 
      showed increased weight and body mass index as well as accumulation of adipose 
      tissue in the visceral, subcutaneous and hepatic areas. These changes were 
      concomitant with decreased levels of BDNF mRNA in the gastro-intestinal tract and 
      increased expression of TrkB mRNA in the brain. Overfeeding did not change the 
      density of cells displaying immunoreactivity for BDNF or TrkB in the brain 
      although both were significantly diminished in the gastro-intestinal tract. These 
      results suggest an involvement of the BDNF/TrkB system in the regulation of food 
      intake and energy balance in zebrafish, as in mammals.
CI  - Copyright (c) 2015 Elsevier GmbH. All rights reserved.
FAU - Montalbano, Giuseppe
AU  - Montalbano G
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy. Electronic address: gmontalbano@unime.it.
FAU - Mania, Manuela
AU  - Mania M
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy.
FAU - Guerrera, Maria Cristina
AU  - Guerrera MC
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy.
FAU - Abbate, Francesco
AU  - Abbate F
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy.
FAU - Laura, Rosaria
AU  - Laura R
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy.
FAU - Navarra, Michele
AU  - Navarra M
AD  - Dipartimento di Scienza del Farmaco e Prodotti per la Salute, Universita di 
      Messina, Polo Universitario SS. Annunziata, 98168 Messina, Italy.
FAU - Vega, Jose A
AU  - Vega JA
AD  - Departamento de Morfologia y Biologia Celular, Facultad de Medicina, Universidad 
      de Oviedo, Av de Julian Claveria 6, 33006 Oviedo, Espana; Facultad de Ciencias de 
      la Salud, Universidad Autonoma de Chile, 5 Poniente, 1670 Talca, Chile.
FAU - Ciriaco, Emilia
AU  - Ciriaco E
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy.
FAU - Germana, Antonino
AU  - Germana A
AD  - Dipartimento di Scienze Veterinarie, 98168 Messina, Italy; Zebrafish 
      Neuromorphology Lab, Universita di Messina, Polo Universitario SS. Annunziata, 
      98168 Messina, Italy.
LA  - eng
PT  - Journal Article
DEP - 20151123
PL  - Germany
TA  - Ann Anat
JT  - Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische 
      Gesellschaft
JID - 100963897
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adipose Tissue/*pathology
MH  - Animals
MH  - Body Mass Index
MH  - Body Weight
MH  - Brain Chemistry/*genetics
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*genetics
MH  - *Diet
MH  - Eating
MH  - Energy Metabolism/genetics
MH  - Gastrointestinal Tract/*metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Obesity/*genetics/*metabolism
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Receptor, trkB/biosynthesis/*genetics
MH  - Zebrafish
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Diet induced obesity
OT  - TrkB
OT  - Zebrafish
EDAT- 2015/12/01 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/12/01 06:00
PHST- 2015/06/16 00:00 [received]
PHST- 2015/10/14 00:00 [revised]
PHST- 2015/11/04 00:00 [accepted]
PHST- 2015/12/01 06:00 [entrez]
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0940-9602(15)00145-4 [pii]
AID - 10.1016/j.aanat.2015.11.003 [doi]
PST - ppublish
SO  - Ann Anat. 2016 Mar;204:36-44. doi: 10.1016/j.aanat.2015.11.003. Epub 2015 Nov 23.