PMID- 26617514
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151130
LR  - 20200929
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 7
DP  - 2015
TI  - Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter 
      Integrity and Long-Term Memory in Aging Mice.
PG  - 213
LID - 10.3389/fnagi.2015.00213 [doi]
LID - 213
AB  - Preservation of brain integrity with age is highly associated with lifespan 
      determination. Caloric restriction (CR) has been shown to increase longevity and 
      healthspan in various species; however, its effects on preserving living brain 
      functions in aging remain largely unexplored. In the study, we used multimodal, 
      non-invasive neuroimaging (PET/MRI/MRS) to determine in vivo brain glucose 
      metabolism, energy metabolites, and white matter structural integrity in young 
      and old mice fed with either control or 40% CR diet. In addition, we determined 
      the animals' memory and learning ability with behavioral assessments. Blood 
      glucose, blood ketone bodies, and body weight were also measured. We found 
      distinct patterns between normal aging and CR aging on brain functions - normal 
      aging showed reductions in brain glucose metabolism, white matter integrity, and 
      long-term memory, resembling human brain aging. CR aging, in contrast, displayed 
      an early shift from glucose to ketone bodies metabolism, which was associated 
      with preservations of brain energy production, white matter integrity, and 
      long-term memory in aging mice. Among all the mice, we found a positive 
      correlation between blood glucose level and body weight, but an inverse 
      association between blood glucose level and lifespan. Our findings suggest that 
      CR could slow down brain aging, in part due to the early shift of energy 
      metabolism caused by lower caloric intake, and we were able to identify the 
      age-dependent effects of CR non-invasively using neuroimaging. These results 
      provide a rationale for CR-induced sustenance of brain health with extended 
      longevity.
FAU - Guo, Janet
AU  - Guo J
AD  - Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY , USA ; 
      Department of Pharmacology and Nutritional Sciences, University of Kentucky , 
      Lexington, KY , USA.
FAU - Bakshi, Vikas
AU  - Bakshi V
AD  - Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY , USA ; 
      Department of Pharmacology and Nutritional Sciences, University of Kentucky , 
      Lexington, KY , USA.
FAU - Lin, Ai-Ling
AU  - Lin AL
AD  - Sanders-Brown Center on Aging, University of Kentucky , Lexington, KY , USA ; 
      Department of Pharmacology and Nutritional Sciences, University of Kentucky , 
      Lexington, KY , USA ; Department of Biomedical Engineering, University of 
      Kentucky , Lexington, KY , USA.
LA  - eng
GR  - K01 AG040164/AG/NIA NIH HHS/United States
GR  - KL2 TR000118/TR/NCATS NIH HHS/United States
GR  - KL2 TR001118/TR/NCATS NIH HHS/United States
GR  - UL1 TR001120/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20151113
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4643125
OTO - NOTNLM
OT  - brain aging
OT  - caloric restriction
OT  - creatine
OT  - glucose metabolism
OT  - ketone bodies
OT  - long-term memory
OT  - neuroimaging
OT  - white matter integrity
EDAT- 2015/12/01 06:00
MHDA- 2015/12/01 06:01
PMCR- 2015/01/01
CRDT- 2015/12/01 06:00
PHST- 2015/08/16 00:00 [received]
PHST- 2015/10/30 00:00 [accepted]
PHST- 2015/12/01 06:00 [entrez]
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2015/12/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2015.00213 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2015 Nov 13;7:213. doi: 10.3389/fnagi.2015.00213. 
      eCollection 2015.