PMID- 26617604
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151130
LR  - 20220409
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 6
DP  - 2015
TI  - Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man.
PG  - 569
LID - 10.3389/fimmu.2015.00569 [doi]
LID - 569
AB  - Dendritic cells (DCs) are highly specialized professional antigen-presenting 
      cells that regulate immune responses, maintaining the balance between tolerance 
      and immunity. Mechanisms via which they can promote central and peripheral 
      tolerance include clonal deletion, the inhibition of memory T cell responses, T 
      cell anergy, and induction of regulatory T cells (Tregs). These properties have 
      led to the analysis of human tolerogenic DCs as a therapeutic strategy for the 
      induction or re-establishment of tolerance. In recent years, numerous protocols 
      for the generation of human tolerogenic DCs have been developed and their 
      tolerogenic mechanisms, including induction of Tregs, are relatively well 
      understood. Phase I trials have been conducted in autoimmune disease, with 
      results that emphasize the feasibility and safety of treatments with tolerogenic 
      DCs. Therefore, the scientific rationale for the use of tolerogenic DCs therapy 
      in the fields of transplantation medicine and allergic and autoimmune diseases is 
      strong. This review will give an overview on efforts and protocols to generate 
      human tolerogenic DCs with focus on IL-10-modulated DCs as inducers of Tregs and 
      discuss their clinical applications and challenges faced in further developing 
      this form of immunotherapy.
FAU - Raker, Verena K
AU  - Raker VK
AD  - Department of Dermatology, University Medical Center Mainz, Johannes 
      Gutenberg-University Mainz , Mainz , Germany.
FAU - Domogalla, Matthias P
AU  - Domogalla MP
AD  - Department of Dermatology, University Medical Center Mainz, Johannes 
      Gutenberg-University Mainz , Mainz , Germany.
FAU - Steinbrink, Kerstin
AU  - Steinbrink K
AD  - Department of Dermatology, University Medical Center Mainz, Johannes 
      Gutenberg-University Mainz , Mainz , Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20151109
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4638142
OTO - NOTNLM
OT  - IL-10
OT  - dendritic cell
OT  - humans
OT  - regulatory T cells
OT  - study
OT  - tolerance
OT  - vaccination
EDAT- 2015/12/01 06:00
MHDA- 2015/12/01 06:01
PMCR- 2015/01/01
CRDT- 2015/12/01 06:00
PHST- 2015/09/17 00:00 [received]
PHST- 2015/10/26 00:00 [accepted]
PHST- 2015/12/01 06:00 [entrez]
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2015/12/01 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2015.00569 [doi]
PST - epublish
SO  - Front Immunol. 2015 Nov 9;6:569. doi: 10.3389/fimmu.2015.00569. eCollection 2015.