PMID- 26617721
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20220408
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 8
IP  - 9
DP  - 2015
TI  - Baicalin ameliorates isoproterenol-induced acute myocardial infarction through 
      iNOS, inflammation and oxidative stress in rat.
PG  - 10139-47
AB  - Baicalin belongs to glucuronic acid glycosides and after hydrolysis baicalein and 
      glucuronic acid come into being. It has such effects as clearing heat and 
      removing toxicity, anti-inflammation, choleresis, bringing high blood pressure 
      down, diuresis, anti-allergic reaction and so on. In this study, we investigated 
      whether baicalin ameliorates isoproterenol-induced acute myocardial infarction 
      and its mechanism. Rat model of acute myocardial infarction was induced by 
      isoproterenol. Casein kinase (CK), the MB isoenzyme of creatine kinase (CK-MB), 
      lactate dehydrogenase (LDH), cardiac troponin T (cTnT) and infarct size 
      measurement were used to measure the protective effect of baicalin on 
      isoproterenol-induced acute myocardial infarction. iNOS protein expression in rat 
      was analyzed using western blot analysis. Tumor necrosis factor-alpha (TNF-alpha), 
      interleukin 6 (IL-6), malondialdehyde (MDA) and superoxide dismutase (SOD) and 
      caspase-3 activation levels were explored using commercial ELISA kits. In the 
      acute myocardial infarction experiment, baicalin effectively ameliorates the 
      level of CK, CK-MB, LDH and cTnT, reduced infarct size in acute myocardial 
      infarction rat model. Meanwhile, treatment with baicalin effectively decreased 
      the iNOS protein expression, inflammatory factors and oxidative stresses in a rat 
      model of acute myocardial infarction. However, baicalin emerged that 
      anti-apoptosis activity and suppressed the activation of caspase-3 in a rat model 
      of acute myocardial infarction. The data suggest that the protective effect of 
      baicalin ameliorates isoproterenol-induced acute myocardial infarction through 
      iNOS, inflammation and oxidative stress in rat.
FAU - Chen, Huaguo
AU  - Chen H
AD  - Department of Emergency, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine 301 Yanchang Road, Shanghai 200072, China.
FAU - Xu, Yongfu
AU  - Xu Y
AD  - Department of Emergency, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine 301 Yanchang Road, Shanghai 200072, China.
FAU - Wang, Jianzhong
AU  - Wang J
AD  - Department of Emergency, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine 301 Yanchang Road, Shanghai 200072, China.
FAU - Zhao, Wei
AU  - Zhao W
AD  - Department of Emergency, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine 301 Yanchang Road, Shanghai 200072, China.
FAU - Ruan, Huihui
AU  - Ruan H
AD  - Department of Emergency, Shanghai Tenth People's Hospital, Tongji University 
      School of Medicine 301 Yanchang Road, Shanghai 200072, China.
LA  - eng
PT  - Journal Article
DEP - 20150901
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Flavonoids)
RN  - 0 (Interleukin-6)
RN  - 0 (Troponin T)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 347Q89U4M5 (baicalin)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.7.11.1 (Casein Kinases)
RN  - EC 2.7.3.2 (Creatine Kinase, MB Form)
RN  - EC 3.4.22.- (Caspase 3)
RN  - L628TT009W (Isoproterenol)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Casein Kinases/blood
MH  - Caspase 3/metabolism
MH  - Creatine Kinase, MB Form/blood
MH  - Enzyme Inhibitors/pharmacology/*therapeutic use
MH  - Flavonoids/pharmacology/*therapeutic use
MH  - Inflammation/drug therapy/metabolism
MH  - Interleukin-6/blood
MH  - Isoproterenol
MH  - L-Lactate Dehydrogenase/blood
MH  - Male
MH  - Malondialdehyde/blood
MH  - Myocardial Infarction/chemically induced/*drug therapy/metabolism
MH  - Nitric Oxide Synthase Type II/*metabolism
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/blood
MH  - Troponin T/metabolism
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC4637536
OTO - NOTNLM
OT  - Baicalin
OT  - INOS
OT  - acute myocardial infarction
OT  - inflammation
OT  - isoproterenol
OT  - oxidative stress
EDAT- 2015/12/01 06:00
MHDA- 2016/10/07 06:00
PMCR- 2015/09/01
CRDT- 2015/12/01 06:00
PHST- 2015/06/25 00:00 [received]
PHST- 2015/07/29 00:00 [accepted]
PHST- 2015/12/01 06:00 [entrez]
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2015 Sep 1;8(9):10139-47. eCollection 2015.