PMID- 26618172
OWN - NLM
STAT- MEDLINE
DCOM- 20160908
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Variations in Antioxidant Genes and Male Infertility.
PG  - 513196
LID - 10.1155/2015/513196 [doi]
LID - 513196
AB  - Oxidative stress and reactive oxygen species (ROS) are generated from both 
      endogenous and environmental resources, which in turn may cause defective 
      spermatogenesis and male infertility. Antioxidant genes, which include catalase 
      (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), nitric 
      oxide synthase (NOS), nuclear factor erythroid 2-related factor 2 (NRF2), and 
      superoxide dismutase (SOD), play important roles in spermatogenesis and normal 
      sperm function. In this review, we discuss the association between variations in 
      major antioxidant genes and male infertility. Numerous studies have suggested 
      that genetic disruption or functional polymorphisms in these antioxidant genes 
      are associated with a higher risk for male infertility, which include low sperm 
      quality, oligoasthenoteratozoospermia, oligozoospermia, and subfertility. The 
      synergistic effects of environmental ROS and functional polymorphisms on 
      antioxidant genes that result in male infertility have also been reported. 
      Therefore, variants in antioxidant genes, which independently or synergistically 
      occur with environmental ROS, affect spermatogenesis and contribute to the 
      occurrence of male infertility. Large cohort and multiple center-based population 
      studies to identify new antioxidant genetic variants that increase susceptibility 
      to male infertility as well as validate its potential as genetic markers for 
      diagnosis and risk assessment for male infertility for precise clinical 
      approaches are warranted.
FAU - Yu, Bolan
AU  - Yu B
AD  - Key Laboratory for Major Obstetric Diseases of Guangdong Province, Third 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China ; 
      Key Laboratory of Reproduction and Genetics of Guangdong Higher Education 
      Institutes, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 
      510150, China.
FAU - Huang, Zhaofeng
AU  - Huang Z
AD  - Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen 
      University, Guangzhou 510080, China ; Department of Biochemistry, Zhongshan 
      School of Medicine, Sun Yat-sen University, Guangzhou 510080, China ; Key 
      Laboratory of Tropical Diseases Control, Sun Yat-sen University, Ministry of 
      Education in China, Guangzhou 510080, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20151105
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Humans
MH  - Infertility, Male/*genetics/*metabolism
MH  - Male
MH  - Reactive Oxygen Species/metabolism
MH  - Spermatogenesis/genetics
MH  - Spermatozoa/metabolism
PMC - PMC4651646
EDAT- 2015/12/01 06:00
MHDA- 2016/09/09 06:00
PMCR- 2015/11/05
CRDT- 2015/12/01 06:00
PHST- 2015/05/21 00:00 [received]
PHST- 2015/09/09 00:00 [revised]
PHST- 2015/10/15 00:00 [accepted]
PHST- 2015/12/01 06:00 [entrez]
PHST- 2015/12/01 06:00 [pubmed]
PHST- 2016/09/09 06:00 [medline]
PHST- 2015/11/05 00:00 [pmc-release]
AID - 10.1155/2015/513196 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:513196. doi: 10.1155/2015/513196. Epub 2015 Nov 5.