PMID- 26620447
OWN - NLM
STAT- MEDLINE
DCOM- 20160927
LR  - 20151219
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Linking)
VI  - 29
IP  - 1
DP  - 2016 Jan
TI  - Reliability and agreement of adipose tissue fat fraction measurements with 
      water-fat MRI in patients with manifest cardiovascular disease.
PG  - 48-56
LID - 10.1002/nbm.3444 [doi]
AB  - The supraclavicular fat depot is known for brown adipose tissue presence. To 
      unravel adipose tissue physiology and metabolism, high quality and reproducible 
      imaging is required. In this study we quantified the reliability and agreement of 
      MRI fat fraction measurements in supraclavicular and subcutaneous adipose tissue 
      of 25 adult patients with clinically manifest cardiovascular disease. MRI fat 
      fraction measurements were made under ambient temperature conditions using a 
      vendor supplied mDixon chemical-shift water-fat multi-echo pulse sequence at 
      1.5 T field strength. Supraclavicular fat fraction reliability (intraclass 
      correlation coefficientagreement , ICCagreement ) was 0.97 for test-retest, 0.95 
      for intra-observer and 0.56 for inter-observer measurements, which increased to 
      0.88 when ICCconsistency was estimated. Supraclavicular fat fraction agreement 
      displayed mean differences of 0.5% (limit of agreement (LoA) -1.7 to 2.6) for 
      test-retest, -0.5% (LoA -2.9 to 2.0) for intra-observer and 5.6% (LoA 0.4 to 
      10.8) for inter-observer measurements. Median fat fraction in supraclavicular 
      adipose tissue was 82.5% (interquartile range (IQR) 78.6-84.0) and 89.7% (IQR 
      87.2-91.5) in subcutaneous adipose tissue (p < 0.0001). In conclusion, water-fat 
      MRI has good reliability and agreement to measure adipose tissue fat fraction in 
      patients with manifest cardiovascular disease. These findings enable research on 
      determinants of fat fraction and enable longitudinal monitoring of fat fraction 
      within adipose tissue depots. Interestingly, even in adult patients with manifest 
      cardiovascular disease, supraclavicular adipose tissue has a lower fat fraction 
      compared with subcutaneous adipose tissue, suggestive of distinct morphologic 
      characteristics, such as brown adipose tissue.
CI  - Copyright (c) 2015 John Wiley & Sons, Ltd.
FAU - Franssens, Bas T
AU  - Franssens BT
AD  - Department of Vascular Medicine, University Medical Center Utrecht, The 
      Netherlands.
FAU - Eikendal, Anouk L
AU  - Eikendal AL
AD  - Department of Radiology, University Medical Center Utrecht, The Netherlands.
FAU - Leiner, Tim
AU  - Leiner T
AD  - Department of Radiology, University Medical Center Utrecht, The Netherlands.
FAU - van der Graaf, Yolanda
AU  - van der Graaf Y
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, The Netherlands.
FAU - Visseren, Frank L J
AU  - Visseren FL
AD  - Department of Vascular Medicine, University Medical Center Utrecht, The 
      Netherlands.
FAU - Hoogduin, J M
AU  - Hoogduin JM
AD  - Department of Radiology, University Medical Center Utrecht, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20151201
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Aged
MH  - Cardiovascular Diseases/*metabolism/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Middle Aged
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - agreement
OT  - brown adipose tissue
OT  - fat fraction
OT  - mDixon MRI
OT  - reliability
OT  - reproducibility
EDAT- 2015/12/02 06:00
MHDA- 2016/09/28 06:00
CRDT- 2015/12/02 06:00
PHST- 2015/07/21 00:00 [received]
PHST- 2015/10/13 00:00 [revised]
PHST- 2015/10/19 00:00 [accepted]
PHST- 2015/12/02 06:00 [entrez]
PHST- 2015/12/02 06:00 [pubmed]
PHST- 2016/09/28 06:00 [medline]
AID - 10.1002/nbm.3444 [doi]
PST - ppublish
SO  - NMR Biomed. 2016 Jan;29(1):48-56. doi: 10.1002/nbm.3444. Epub 2015 Dec 1.