PMID- 26620985
OWN - NLM
STAT- MEDLINE
DCOM- 20161102
LR  - 20181113
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 36
IP  - 12
DP  - 2015 Dec
TI  - Effects of 12-month, 2000IU/day vitamin D supplementation on treatment naive and 
      vitamin D deficient Saudi type 2 diabetic patients.
PG  - 1432-8
LID - 10.15537/smj.2015.12.12923 [doi]
AB  - OBJECTIVES: To determine whether 12-month, 2000IU/day vitamin D supplementation 
      cardiometabolically improves treatment naive type 2 diabetes mellitus (T2DM) 
      Saudi patients with vitamin D deficiency.  METHODS: This 12-month interventional 
      study was conducted at primary health centers in 5 different residential areas in 
      Riyadh, Saudi Arabia between January 2013 and January 2014. Forty-five Saudi  
      T2DM  patients were enrolled. Baseline anthropometrics, glycemic, and lipid 
      profiles were measured and repeated after 6 and 12 months. All subjects were 
      provided with 2000IU vitamin D supplements for one year.   RESULTS: Vitamin D 
      deficiency at baseline was 46.7%, 31.8% after 6 months, and 35.6% after 12 
      months, indicating an overall improvement in the vitamin D status in the entire 
      cohort. Insulin and homeostatic model assessment-insulin resistance (HOMA-IR) 
      after 12 months were significantly lower than a 6 months (p less than 0.05), but 
      comparable to baseline values. Mean levels of triglycerides increased overtime 
      from baseline (1.9+/-0.01 mmol/l) to 12 months (2.1+/-0.2 mmol). This modest increase 
      in serum triglycerides was parallel to the insignificant decrease in circulating 
      high-density lipoprotein -cholesterol levels.  CONCLUSION: Twelve-month vitamin D 
      supplementation of 2000IU per day in a cohort of treatment naive Saudi patients 
      with T2DM resulted in improvement of several cardiometabolic parameters including 
      systolic blood pressure, insulin, and HOMA-IR. Further studies that include a 
      placebo group are suggested to reinforce findings.
FAU - Al-Shahwan, May A
AU  - Al-Shahwan MA
AD  - Department of Community Health Sciences, College of Science, King Saud 
      University, Riyadh, Kingdom of Saudi Arabia. E-mail. mayalshahwan@ksu.edu.sa.
FAU - Al-Othman, Abdulaziz M
AU  - Al-Othman AM
FAU - Al-Daghri, Nasser M
AU  - Al-Daghri NM
FAU - Sabico, Shaun B
AU  - Sabico SB
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Saudi Arabia
MH  - Vitamin D/*administration & dosage
MH  - Vitamin D Deficiency/complications/*drug therapy
PMC - PMC4707399
EDAT- 2015/12/02 06:00
MHDA- 2016/11/03 06:00
PMCR- 2015/12/01
CRDT- 2015/12/02 06:00
PHST- 2015/12/02 06:00 [entrez]
PHST- 2015/12/02 06:00 [pubmed]
PHST- 2016/11/03 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - SaudiMedJ-36-1432 [pii]
AID - 10.15537/smj.2015.12.12923 [doi]
PST - ppublish
SO  - Saudi Med J. 2015 Dec;36(12):1432-8. doi: 10.15537/smj.2015.12.12923.