PMID- 26621249
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 103
DP  - 2016 Jan
TI  - PPARalpha in lysosomal biogenesis: A perspective.
PG  - 144-8
LID - S1043-6618(15)30163-8 [pii]
LID - 10.1016/j.phrs.2015.11.011 [doi]
AB  - Lysosomes are membrane-bound vesicles containing hydrolytic enzymes, ubiquitously 
      present in all eukaryotic cells. Classically considered to be central to the 
      cellular waste management machinery, recent studies revealed the role of 
      lysosomes in a wide array of cellular processes like, degradation, cellular 
      development, programmed cell death, secretion, plasma membrane repair, 
      nutritional responses, and lipid metabolism. We recently studied the regulation 
      of TFEB, considered to be the master regulator of lysosomal biogenesis, by 
      activation of peroxisomal proliferator activated receptor alpha (PPARalpha), one of the 
      key regulators of lipid metabolism. In this article, we discuss how the recent 
      finding could be put in to perspective with the previous findings that relate 
      lysosomal biogenesis to lipid metabolism, and comment on the possibility of a 
      bi-directional interplay between these two distinct cellular processes upon 
      activation of PPARalpha.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Ghosh, Arunava
AU  - Ghosh A
AD  - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 
      United States.
FAU - Pahan, Kalipada
AU  - Pahan K
AD  - Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, 
      United States; Division of Research and Development, Jesse Brown Veterans Affairs 
      Medical Center, 820 South Damen Avenue, Chicago, IL,United States. Electronic 
      address: Kalipada_Pahan@rush.edu.
LA  - eng
GR  - I01 BX003033/BX/BLRD VA/United States
GR  - R01 NS083054/NS/NINDS NIH HHS/United States
GR  - R01 AT006681/AT/NCCIH NIH HHS/United States
GR  - NS083054/NS/NINDS NIH HHS/United States
GR  - AT6681/AT/NCCIH NIH HHS/United States
PT  - Letter
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151124
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (PPAR alpha)
RN  - 0 (TFEB protein, human)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*metabolism
MH  - Humans
MH  - *Lipid Metabolism
MH  - Lysosomes/*metabolism
MH  - PPAR alpha/*metabolism
PMC - PMC4861553
MID - NIHMS782740
OTO - NOTNLM
OT  - Fibrate drugs
OT  - Lipid metabolism
OT  - Lysosomal biogenesis
OT  - PPARalpha
OT  - TFEB
EDAT- 2015/12/02 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/05/09
CRDT- 2015/12/02 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2015/11/13 00:00 [revised]
PHST- 2015/11/15 00:00 [accepted]
PHST- 2015/12/02 06:00 [entrez]
PHST- 2015/12/02 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/05/09 00:00 [pmc-release]
AID - S1043-6618(15)30163-8 [pii]
AID - 10.1016/j.phrs.2015.11.011 [doi]
PST - ppublish
SO  - Pharmacol Res. 2016 Jan;103:144-8. doi: 10.1016/j.phrs.2015.11.011. Epub 2015 Nov 
      24.