PMID- 26622294
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151201
LR  - 20200929
IS  - 1735-7020 (Print)
IS  - 2008-238X (Electronic)
IS  - 1735-7020 (Linking)
VI  - 10
IP  - 3
DP  - 2015 Jul-Sep
TI  - Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria 
      Infection in Mice.
PG  - 389-401
AB  - BACKGROUND: Interleukin 18 (IL-18) exerts pleiotropic roles in many 
      inflammatory-related diseases including parasitic infection. Previous studies 
      have demonstrated the promising therapeutic potential of modulating IL-18 
      bioactivity in various pathological conditions. However, its involvement during 
      malaria infection has yet to be established. In this study, we demonstrated the 
      effect of modulating IL-18 on the histopathological conditions of malaria 
      infected mice. METHODS: Plasmodium berghei ANKA infection in male ICR mice was 
      used as a model for malaria infection. Modulation of IL-18 release was carried 
      out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and 
      recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological 
      study and analysis were performed on major organs including brain, liver, spleen, 
      lungs and kidney. RESULTS: Treatment with rmIL-18Fc resulted in significant 
      improvements on the histopathological conditions of the organs in 
      malaria-infected mice. CONCLUSION: IL-18 is an important mediator of malaria 
      pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
FAU - Jabbarzare, Marzieh
AU  - Jabbarzare M
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Chin, Voon Kin
AU  - Chin VK
AD  - Dept. of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti 
      Putra Malaysia, Selangor, Malaysia.
FAU - Talib, Herni
AU  - Talib H
AD  - Dept. of Pathology, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Yam, Mun Fei
AU  - Yam MF
AD  - School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
FAU - Adam, Siti Khadijah
AU  - Adam SK
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Hassan, Haniza
AU  - Hassan H
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Abdul Majid, Roslaini
AU  - Abdul Majid R
AD  - Dept. of Medical Microbiology and Parasitology, Faculty of Medicine & Health 
      Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
FAU - Mat Taib, Che Norma
AU  - Mat Taib CN
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Mohd Moklas, Mohamad Aris
AU  - Mohd Moklas MA
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Taufik Hidayat, Mohamad
AU  - Taufik Hidayat M
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
FAU - Mohd Sidek, Hasidah
AU  - Mohd Sidek H
AD  - School of Biosciences and Biotechnology, Faculty of Science and Technology, 
      Universiti Kebangsaan Malaysia, Malaysia.
FAU - Basir, Rusliza
AU  - Basir R
AD  - Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra 
      Malaysia, Selangor, Malaysia.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Parasitol
JT  - Iranian journal of parasitology
JID - 101464309
PMC - PMC4662739
OTO - NOTNLM
OT  - Histopathology
OT  - Interleukin-18
OT  - Malaria
OT  - Plasmodium berghei
EDAT- 2015/12/02 06:00
MHDA- 2015/12/02 06:01
PMCR- 2015/07/01
CRDT- 2015/12/02 06:00
PHST- 2015/12/02 06:00 [entrez]
PHST- 2015/12/02 06:00 [pubmed]
PHST- 2015/12/02 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - IJPA-10-389 [pii]
PST - ppublish
SO  - Iran J Parasitol. 2015 Jul-Sep;10(3):389-401.