PMID- 26622578
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 10
IP  - 2
DP  - 2015 Aug
TI  - S6K1 inhibition enhances the apoptotic cell death of breast cancer cells in 
      response to Bcl-2/Bcl-xL inhibition by the downregulation of survivin.
PG  - 829-834
AB  - Breast cancer cells possess a deregulated apoptotic pathway with increased 
      expression levels of anti-apoptotic B-cell lymphoma-2 (Bcl-2) family proteins and 
      ribosomal S6 kinase 1 (S6K1) protein activity. Therefore, combined interference 
      of anti-apoptotic Bcl-2 family and S6K1 protein expression may be a reasonable 
      therapeutic strategy for the treatment of patients with breast cancer. In the 
      present study, it was identified that the administration of a combination of 
      ABT263 [navitoclax; a Bcl-2/Bcl-extra large (Bcl-xL) inhibitor] and PF4708671 (an 
      S6K1 inhibitor) markedly increased apoptotic cell death in the BT474 breast 
      cancer cells compared with the administration of either agent alone. Furthermore, 
      the downregulation of Bcl-2/Bcl-xL and S6K1 with small interfering RNA induced a 
      significant increase in cell death compared with RNA interference of either agent 
      alone. Notably, combination treatment with ABT263 and PF4708671 decreased the 
      expression level of survivin protein, with this ectopic expression of survivin 
      attenuating cell death. Thus, the present study determined that the combined 
      inhibition of Bcl-2/Bcl-xL and S6K1 may be a good strategy for treating patients 
      with breast cancer.
FAU - Park, Jin-Ah
AU  - Park JA
AD  - KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, 
      Seoul 139-706, Republic of Korea ; Department of Biological Sciences, College of 
      Natural Sciences, Kangwon National University, Chuncheon 200-701, Republic of 
      Korea.
FAU - Jin, Hyeon-Ok
AU  - Jin HO
AD  - KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, 
      Seoul 139-706, Republic of Korea.
FAU - Lee, Ha-Na
AU  - Lee HN
AD  - KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, 
      Seoul 139-706, Republic of Korea.
FAU - Kim, Jin-Hee
AU  - Kim JH
AD  - KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, 
      Seoul 139-706, Republic of Korea.
FAU - Park, In-Chul
AU  - Park IC
AD  - Division of Radiation Cancer Research, Korea Institute of Radiological and 
      Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Noh, Woo Chul
AU  - Noh WC
AD  - Department of Surgery, Korea Cancer Center Hospital, Korea Institute of 
      Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Chang, Yoon Hwan
AU  - Chang YH
AD  - Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute 
      of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Hong, Young Jun
AU  - Hong YJ
AD  - Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute 
      of Radiological and Medical Sciences, Seoul 139-706, Republic of Korea.
FAU - Kim, Keun-Chul
AU  - Kim KC
AD  - Department of Biological Sciences, College of Natural Sciences, Kangwon National 
      University, Chuncheon 200-701, Republic of Korea.
FAU - Lee, Jin Kyung
AU  - Lee JK
AD  - KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, 
      Seoul 139-706, Republic of Korea ; Department of Laboratory Medicine, Korea 
      Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, 
      Seoul 139-706, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20150611
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4509134
OTO - NOTNLM
OT  - B-cell lymphoma-2
OT  - B-cell lymphoma-extra large
OT  - breast cancer
OT  - ribosomal S6 kinase 1
OT  - survivin
EDAT- 2015/12/02 06:00
MHDA- 2015/12/02 06:01
PMCR- 2015/06/11
CRDT- 2015/12/02 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2015/04/27 00:00 [accepted]
PHST- 2015/12/02 06:00 [entrez]
PHST- 2015/12/02 06:00 [pubmed]
PHST- 2015/12/02 06:01 [medline]
PHST- 2015/06/11 00:00 [pmc-release]
AID - OL-0-0-3369 [pii]
AID - 10.3892/ol.2015.3369 [doi]
PST - ppublish
SO  - Oncol Lett. 2015 Aug;10(2):829-834. doi: 10.3892/ol.2015.3369. Epub 2015 Jun 11.