PMID- 26623654 OWN - NLM STAT- MEDLINE DCOM- 20160623 LR - 20220129 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 12 DP - 2015 TI - A Randomised Controlled Trial to Reduce Sedentary Time in Young Adults at Risk of Type 2 Diabetes Mellitus: Project STAND (Sedentary Time ANd Diabetes). PG - e0143398 LID - 10.1371/journal.pone.0143398 [doi] LID - e0143398 AB - AIMS: Type 2 diabetes mellitus (T2DM), a serious and prevalent chronic disease, is traditionally associated with older age. However, due to the rising rates of obesity and sedentary lifestyles, it is increasingly being diagnosed in the younger population. Sedentary (sitting) behaviour has been shown to be associated with greater risk of cardio-metabolic health outcomes, including T2DM. Little is known about effective interventions to reduce sedentary behaviour in younger adults at risk of T2DM. We aimed to investigate, through a randomised controlled trial (RCT) design, whether a group-based structured education workshop focused on sitting reduction, with self-monitoring, reduced sitting time. METHODS: Adults aged 18-40 years who were either overweight (with an additional risk factor for T2DM) or obese were recruited for the Sedentary Time ANd Diabetes (STAND) RCT. The intervention programme comprised of a 3-hour group-based structured education workshop, use of a self-monitoring tool, and follow-up motivational phone call. Data were collected at three time points: baseline, 3 and 12 months after baseline. The primary outcome measure was accelerometer-assessed sedentary behaviour after 12 months. Secondary outcomes included other objective (activPAL) and self-reported measures of sedentary behaviour and physical activity, and biochemical, anthropometric, and psycho-social variables. RESULTS: 187 individuals (69% female; mean age 33 years; mean BMI 35 kg/m2) were randomised to intervention and control groups. 12 month data, when analysed using intention-to-treat analysis (ITT) and per-protocol analyses, showed no significant difference in the primary outcome variable, nor in the majority of the secondary outcome measures. CONCLUSIONS: A structured education intervention designed to reduce sitting in young adults at risk of T2DM was not successful in changing behaviour at 12 months. Lack of change may be due to the brief nature of such an intervention and lack of focus on environmental change. Moreover, some participants reported a focus on physical activity rather than reductions in sitting per se. The habitual nature of sedentary behaviour means that behaviour change is challenging. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN08434554. FAU - Biddle, Stuart J H AU - Biddle SJ AD - School of Sport, Exercise & Health Sciences, Loughborough University, Loughborough, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Edwardson, Charlotte L AU - Edwardson CL AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Wilmot, Emma G AU - Wilmot EG AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. FAU - Yates, Thomas AU - Yates T AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Gorely, Trish AU - Gorely T AD - School of Health Sciences, University of Stirling, Stirling, United Kingdom. FAU - Bodicoat, Danielle H AU - Bodicoat DH AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Ashra, Nuzhat AU - Ashra N AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Khunti, Kamlesh AU - Khunti K AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Nimmo, Myra A AU - Nimmo MA AD - School of Sport, Exercise & Health Sciences, Loughborough University, Loughborough, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. FAU - Davies, Melanie J AU - Davies MJ AD - Leicester Diabetes Research Centre, University of Leicester, Leicester, United Kingdom. AD - The NIHR Leicester Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, Leicester and Loughborough, United Kingdom. LA - eng SI - ISRCTN/ISRCTN08434554 GR - G0802131/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20151201 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Adult MH - Diabetes Mellitus, Type 2/*complications/prevention & control/psychology MH - Female MH - Health Promotion/*methods MH - Humans MH - Male MH - Obesity/complications MH - Risk MH - *Sedentary Behavior MH - Young Adult PMC - PMC4666612 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2015/12/02 06:00 MHDA- 2016/06/24 06:00 PMCR- 2015/12/01 CRDT- 2015/12/02 06:00 PHST- 2015/07/28 00:00 [received] PHST- 2015/11/03 00:00 [accepted] PHST- 2015/12/02 06:00 [entrez] PHST- 2015/12/02 06:00 [pubmed] PHST- 2016/06/24 06:00 [medline] PHST- 2015/12/01 00:00 [pmc-release] AID - PONE-D-15-30570 [pii] AID - 10.1371/journal.pone.0143398 [doi] PST - epublish SO - PLoS One. 2015 Dec 1;10(12):e0143398. doi: 10.1371/journal.pone.0143398. eCollection 2015.