PMID- 26625776
OWN - NLM
STAT- MEDLINE
DCOM- 20160926
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 17
DP  - 2015
TI  - Clinical Significance of the NQO1 C609T Polymorphism in Non Small Cell Lung 
      Adenocarcinoma Patients.
PG  - 7653-8
AB  - NAD(P)H: quinone oxidoreductase 1 (NQO1) is part of the antioxidant defence 
      system involved in detoxification. This study aimed to analyze the influence of 
      NQO1 (C609T) genetic polymorphism in non small cell lung cancer (NSCLC)as a 
      putative risk factor. MATERIALS AND METHODS: Present study included 100 cases of 
      NSCLC (adenocarcinoma) patients and 100 age and sex matched healthy controls. 
      NQO1 (C609T) genotyping was performed by allele specific PCR for assessment of 
      putative associations with clinical outcome and genotypes of. The association of 
      the polymorphism with the survival of NSCLC patients' was analyzed by 
      Kaplan-Meier method. RESULTS: In Indian NSCLC (adenocarcinoma) patients increased 
      risk of developing NSCLC was found to be associated with NQO1 609TT genotype [OR 
      3.68(0.90-14.98), RR 2.04(0.78-5.31)] for CT [OR 2.91(1.58- 5.34), RR 
      1.74(1.23-2.44) p= 0.0005 for CT], for CT+TT [ OR 3.26(1.82-5.82), RR 
      1.87(1.34-2.61) p<0.0001 for CT+TT]. A significant difference (p=0.0009) was 
      observed in genotype distribution among cases and healthy controls. Patients with 
      CT+TT genotype exhibited a significant poor overall survival compared with 
      patients displaying homozygous CC genotype (p=0.03) and when survival 
      independently compared with CC, TT and CT genotype was also found to be 
      significantly associated (p=0.02). Overall median survival times were CT 6.0 
      months, TT 8.2 months, and CT + TT (6.4 months)]. CONCLUSIONS: The present study 
      revealed that NQO1 CT, TT and CT+TT genotypes may be associated with clinical 
      outcome and risk of developing NSCLC in the Indian population.
FAU - Masroor, Mirza
AU  - Masroor M
AD  - Biochemistry, Maulana Azad Medical College, New Delhi, India E-mail : 
      biochempublications@gmail.com.
FAU - Jain, Amit
AU  - Jain A
FAU - Javid, Jamsheed
AU  - Javid J
FAU - Mir, Rashid
AU  - Mir R
FAU - Prashant, Y
AU  - Prashant Y
FAU - Imtiyaz, A
AU  - Imtiyaz A
FAU - Mariyam, Z
AU  - Mariyam Z
FAU - Mohan, Anant
AU  - Mohan A
FAU - Ray, P C
AU  - Ray PC
FAU - Saxena, Alpana
AU  - Saxena A
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
RN  - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
RN  - EC 1.6.5.2 (NQO1 protein, human)
SB  - IM
MH  - Adenocarcinoma/*genetics/mortality
MH  - Adenocarcinoma of Lung
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/mortality
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Lung Neoplasms/*genetics/mortality
MH  - Male
MH  - Middle Aged
MH  - NAD(P)H Dehydrogenase (Quinone)/*genetics
MH  - Nucleic Acid Amplification Techniques
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
EDAT- 2015/12/03 06:00
MHDA- 2016/09/27 06:00
CRDT- 2015/12/03 06:00
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/09/27 06:00 [medline]
AID - 10.7314/apjcp.2015.16.17.7653 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(17):7653-8. doi: 10.7314/apjcp.2015.16.17.7653.