PMID- 26625862
OWN - NLM
STAT- MEDLINE
DCOM- 20160923
LR  - 20220409
IS  - 1473-6543 (Electronic)
IS  - 1062-4821 (Linking)
VI  - 25
IP  - 1
DP  - 2016 Jan
TI  - Monocyte chemoattractant protein-1 and the kidney.
PG  - 42-9
LID - 10.1097/MNH.0000000000000186 [doi]
AB  - PURPOSE OF REVIEW: Recently, initial studies have been carried out in patients 
      using monocyte chemoattractant protein-1 (MCP-1) inhibitors. This review 
      summarizes the known function of MCP-1 in regulating monocytes during 
      inflammation and its role in inflammatory disease of the kidney. RECENT FINDINGS: 
      MCP-1 is one of the first chemokines described and plays an important role in 
      renal inflammatory disease. The function of MCP-1 has been investigated and 
      analyzed in both animal models of renal disease and renal patients. MCP-1 
      mediates firstly the release of monocytes from the bone marrow, and then 
      generates a gradient in the endothelial glycocalyx to direct monocytes to sites 
      of inflammation, thereby alleviating the migration of blood leukocytes into the 
      inflamed tissue. In addition, MCP-1 has direct signaling effects in monocytes and 
      influences migration, proliferation, and differentiation of leukocytes. Blockade 
      of MCP-1 in several models of renal disease has ameliorated the disease, 
      suggesting that inhibition of MCP-1 is a promising and valid strategy to treat 
      patients with renal inflammatory disease. SUMMARY: Understanding the role of 
      MCP-1 in monocyte homeostasis and the implications of MCP-1 inhibition in renal 
      disease will help in designing better diagnostic and therapeutic strategies in 
      patients with inflammatory renal disease.
FAU - Haller, Hermann
AU  - Haller H
AD  - Department of Nephrology and Hypertension, Medizinische Hochschule Hannover, 
      Hannover, Germany.
FAU - Bertram, Anna
AU  - Bertram A
FAU - Nadrowitz, Felix
AU  - Nadrowitz F
FAU - Menne, Jan
AU  - Menne J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Nephrol Hypertens
JT  - Current opinion in nephrology and hypertension
JID - 9303753
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Cell Movement
MH  - Chemokine CCL2/antagonists & inhibitors/*physiology
MH  - Diabetic Nephropathies/etiology
MH  - Humans
MH  - Kidney/physiology
MH  - Kidney Diseases/*etiology
MH  - Monocytes/physiology
MH  - Nephritis/etiology
MH  - Vasculitis/etiology
EDAT- 2015/12/03 06:00
MHDA- 2016/09/24 06:00
CRDT- 2015/12/03 06:00
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/09/24 06:00 [medline]
AID - 10.1097/MNH.0000000000000186 [doi]
PST - ppublish
SO  - Curr Opin Nephrol Hypertens. 2016 Jan;25(1):42-9. doi: 
      10.1097/MNH.0000000000000186.