PMID- 26625863
OWN - NLM
STAT- MEDLINE
DCOM- 20160923
LR  - 20211203
IS  - 1473-6543 (Electronic)
IS  - 1062-4821 (Print)
IS  - 1062-4821 (Linking)
VI  - 25
IP  - 1
DP  - 2016 Jan
TI  - The role of mechanistic target of rapamycin in maintenance of glomerular 
      epithelial cells.
PG  - 28-34
LID - 10.1097/MNH.0000000000000181 [doi]
AB  - PURPOSE OF REVIEW: Recent studies have emerged to reveal the pivotal roles of 
      mechanistic target of rapamycin (mTOR) signaling not only in the maintenance of 
      the physiological functions of renal cells but also in the pathogenesis of renal 
      cell dysfunctions and kidney diseases. We introduce the current understanding of 
      mTOR signaling, and its crucial roles in glomerular epithelial cell biology and 
      the pathophysiology related to kidney diseases. RECENT FINDINGS: mTOR, a Ser/Thr 
      kinase, forms two distinct functional complexes, mTORC1 and mTORC2. Recent 
      studies revealed that physiologic levels of mTORC1 and mTORC2 activity play key 
      roles in maintaining podocyte and glomerular functions. However, aberrant 
      activation of mTORC1 or loss of mTORC2 activity in podocytes may underlie the 
      pathogenesis of glomerular disorders, including diabetic kidney disease. SUMMARY: 
      An effective treatment for mTORC1-associated podocyte and glomerular dysfunction 
      may require the attenuation of mTORC1 activity in the setting of both an intact 
      mTORC2 pathway and normal basal mTORC1 activity in order to preserve physiologic 
      podocyte functions.
FAU - Yao, Yao
AU  - Yao Y
AD  - aLife Sciences Institute bDepartment of Molecular and Integrative Physiology 
      cDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 
      USA.
FAU - Inoki, Ken
AU  - Inoki K
LA  - eng
GR  - R01 DK083491/DK/NIDDK NIH HHS/United States
GR  - R01 GM110019/GM/NIGMS NIH HHS/United States
GR  - DK083491/DK/NIDDK NIH HHS/United States
GR  - GM110019/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Curr Opin Nephrol Hypertens
JT  - Current opinion in nephrology and hypertension
JID - 9303753
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Epithelial Cells/*physiology
MH  - Humans
MH  - Kidney Glomerulus/cytology/*physiology
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Multiprotein Complexes/physiology
MH  - Podocytes/physiology
MH  - Signal Transduction/physiology
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases/*physiology
PMC - PMC4911704
MID - NIHMS747531
EDAT- 2015/12/03 06:00
MHDA- 2016/09/24 06:00
PMCR- 2017/01/01
CRDT- 2015/12/03 06:00
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/09/24 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.1097/MNH.0000000000000181 [doi]
PST - ppublish
SO  - Curr Opin Nephrol Hypertens. 2016 Jan;25(1):28-34. doi: 
      10.1097/MNH.0000000000000181.