PMID- 26625944 OWN - NLM STAT- MEDLINE DCOM- 20160509 LR - 20191210 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 6 DP - 2015 Dec 2 TI - Transformable liquid-metal nanomedicine. PG - 10066 LID - 10.1038/ncomms10066 [doi] LID - 10066 AB - To date, numerous inorganic nanocarriers have been explored for drug delivery systems (DDSs). However, the clinical application of inorganic formulations has often been hindered by their toxicity and failure to biodegrade. We describe here a transformable liquid-metal nanomedicine, based on a core-shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell. This formulation can be simply produced through a sonication-mediated method with bioconjugation flexibility. The resulting nanoparticles loaded with doxorubicin (Dox) have an average diameter of 107 nm and demonstrate the capability to fuse and subsequently degrade under a mildly acidic condition, which facilitates release of Dox in acidic endosomes after cellular internalization. Equipped with hyaluronic acid, a tumour-targeting ligand, this formulation displays enhanced chemotherapeutic inhibition towards the xenograft tumour-bearing mice. This liquid metal-based DDS with fusible and degradable behaviour under physiological conditions provides a new strategy for engineering theranostic agents with low toxicity. FAU - Lu, Yue AU - Lu Y AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. AD - Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. FAU - Hu, Quanyin AU - Hu Q AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. AD - Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. FAU - Lin, Yiliang AU - Lin Y AD - Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA. FAU - Pacardo, Dennis B AU - Pacardo DB AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. AD - Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. FAU - Wang, Chao AU - Wang C AUID- ORCID: 0000-0002-8054-3472 AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. AD - Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. FAU - Sun, Wujin AU - Sun W AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. AD - Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. FAU - Ligler, Frances S AU - Ligler FS AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. FAU - Dickey, Michael D AU - Dickey MD AD - Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA. FAU - Gu, Zhen AU - Gu Z AD - Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA. AD - Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. AD - Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. LA - eng GR - UL1 TR001111/TR/NCATS NIH HHS/United States GR - 1UL1TR001111/TR/NCATS NIH HHS/United States PT - Evaluation Study PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20151202 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 RN - 0 (Antineoplastic Agents) RN - 0 (Drug Carriers) RN - 045A6V3VFX (Indium) RN - 80168379AG (Doxorubicin) RN - CH46OC8YV4 (Gallium) SB - IM MH - Animals MH - Antineoplastic Agents/*administration & dosage/chemistry MH - Cell Line, Tumor MH - Doxorubicin/*administration & dosage/chemistry MH - Drug Carriers/*chemistry MH - Drug Delivery Systems/instrumentation/*methods MH - Female MH - Gallium/*chemistry MH - Humans MH - Indium/*chemistry MH - Metal Nanoparticles/*chemistry MH - Mice MH - Mice, Inbred BALB C MH - Nanomedicine/instrumentation/*methods MH - Neoplasms/*drug therapy PMC - PMC4686762 EDAT- 2015/12/03 06:00 MHDA- 2016/05/10 06:00 PMCR- 2015/12/22 CRDT- 2015/12/03 06:00 PHST- 2015/05/11 00:00 [received] PHST- 2015/10/29 00:00 [accepted] PHST- 2015/12/03 06:00 [entrez] PHST- 2015/12/03 06:00 [pubmed] PHST- 2016/05/10 06:00 [medline] PHST- 2015/12/22 00:00 [pmc-release] AID - ncomms10066 [pii] AID - 10.1038/ncomms10066 [doi] PST - epublish SO - Nat Commun. 2015 Dec 2;6:10066. doi: 10.1038/ncomms10066.