PMID- 26626949
OWN - NLM
STAT- MEDLINE
DCOM- 20160726
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 230
IP  - 3
DP  - 2015 Dec 30
TI  - Evaluating the relationship between cannabis use and IQ in youth and young adults 
      at clinical high risk of psychosis.
PG  - 878-84
LID - S0165-1781(15)30166-9 [pii]
LID - 10.1016/j.psychres.2015.11.033 [doi]
AB  - Among people with psychosis, those with a history of cannabis use show better 
      cognitive performance than those who are cannabis naive. It is unknown whether 
      this pattern is present in youth at clinical high risk (CHR) of psychosis. We 
      evaluated relationships between IQ and cannabis use while controlling for use of 
      other substances known to impact cognition in 678 CHR and 263 healthy control 
      (HC) participants. IQ was estimated using the Vocabulary and Block Design 
      subtests of the Wechsler Abbreviated Scale of Intelligence. Drug and alcohol use 
      severity and frequency were assessed with the Alcohol and Drug Use Scale, and we 
      inquired participants' age at first use. CHR were further separated into early 
      and late age at onset of cannabis use sub-groups, and low-, moderate- and 
      high-frequency sub-groups. No significant differences in IQ emerged between CHR 
      or HC cannabis users vs. non-users, or between use frequency groups. CHR 
      late-onset users showed significantly higher IQ than CHR early-onset users. Age 
      at onset of cannabis use was significantly and positively correlated with IQ in 
      CHR only. Results suggest that age at onset of cannabis may be a more important 
      factor for IQ than use current use or use frequency in CHR.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Buchy, Lisa
AU  - Buchy L
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
FAU - Seidman, Larry J
AU  - Seidman LJ
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center, Boston, MA, United States.
FAU - Cadenhead, Kristin S
AU  - Cadenhead KS
AD  - Department of Psychiatry, UCSD, La Jolla, CA, United States.
FAU - Cannon, Tyrone D
AU  - Cannon TD
AD  - Department of Psychology, Yale University, New Haven, CT, United States.
FAU - Cornblatt, Barbara A
AU  - Cornblatt BA
AD  - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United 
      States.
FAU - McGlashan, Thomas H
AU  - McGlashan TH
AD  - Department of Psychiatry, Yale University, New Haven, CT, United States.
FAU - Perkins, Diana O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, United 
      States; Massachusetts General Hospital, Boston, MA, United States.
FAU - Stone, William
AU  - Stone W
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center, Boston, MA, United States.
FAU - Tsuang, Ming T
AU  - Tsuang MT
AD  - Department of Psychiatry, UCSD, La Jolla, CA, United States.
FAU - Walker, Elaine F
AU  - Walker EF
AD  - Departments of Psychology and Psychiatry, Emory University, Atlanta, GA, United 
      States.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United 
      States.
FAU - Bearden, Carrie E
AU  - Bearden CE
AD  - Departments of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los 
      Angeles, CA, United States.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - University of California, San Francisco, CA, United States.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. 
      Electronic address: jmadding@ucalgary.ca.
LA  - eng
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01MH082004/MH/NIMH NIH HHS/United States
GR  - P50MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - K24MH76191/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - U01MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - U01MH081857-05/MH/NIMH NIH HHS/United States
GR  - R01MH60720/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH076989/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - U01MH081902/MH/NIMH NIH HHS/United States
GR  - P50MH080272/MH/NIMH NIH HHS/United States
GR  - U01MH081984/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151125
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Alcohol Drinking/psychology
MH  - Child
MH  - Cognition/*physiology
MH  - Female
MH  - Humans
MH  - Intelligence/*physiology
MH  - Intelligence Tests
MH  - Male
MH  - Marijuana Smoking/*psychology
MH  - Psychotic Disorders/*psychology
MH  - Risk
MH  - Young Adult
PMC - PMC5037441
MID - NIHMS740052
OTO - NOTNLM
OT  - Age at onset
OT  - Alcohol
OT  - Cannabis
OT  - IQ
OT  - Prodrome
OT  - Schizophrenia
COIS- All authors declare no conflict of interest.
EDAT- 2015/12/03 06:00
MHDA- 2016/07/28 06:00
PMCR- 2016/12/30
CRDT- 2015/12/03 06:00
PHST- 2015/08/15 00:00 [received]
PHST- 2015/11/12 00:00 [revised]
PHST- 2015/11/13 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/07/28 06:00 [medline]
PHST- 2016/12/30 00:00 [pmc-release]
AID - S0165-1781(15)30166-9 [pii]
AID - 10.1016/j.psychres.2015.11.033 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Dec 30;230(3):878-84. doi: 10.1016/j.psychres.2015.11.033. 
      Epub 2015 Nov 25.