PMID- 2662729
OWN - NLM
STAT- MEDLINE
DCOM- 19890801
LR  - 20190626
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 118
IP  - 1
DP  - 1989 Jul
TI  - Antianginal and cardiac metabolic effects of low-dose glucose infusion during 
      pacing in patients with and without coronary artery disease.
PG  - 25-32
AB  - Anginal threshold and cardiac metabolism during infusion of glucose, 350 mg/min, 
      were compared with control values before, during, and after pacing in nine 
      patients with coronary artery disease (CAD) and nine patients without coronary 
      artery disease (non-CAD). Pacing induced no ischemia in non-CAD patients; in CAD 
      patients, intolerable angina developed in less than 5 minutes. However, glucose 
      infusion in the latter group increased the time to onset of angina (110 +/- 24 
      seconds before infusion versus 140 +/- 24 seconds following infusion) and 
      decreased the extent of ST segment depression (1.8 +/- 0.3 mm before infusion 
      versus 0.9 +/- 0.2 mm following infusion, p less than 0.01) following pacing. In 
      all subjects, arterial levels and cardiac uptake of glucose rose by 100% (p less 
      than 0.001) and those of free fatty acids fell by 50% (p less than 0.01). 
      Arterial lactate and uptake of lactate by nonischemic myocardium increased by 30% 
      (p less than 0.05). During pacing in CAD patients, this elevated uptake was 
      outweighed by similar increases of lactate release from ischemic areas, leaving 
      mean negative global exchanges unaltered. In CAD patients solely, rebuilding of 
      cardiac glycogen after pacing was suggested from augmented citrate efflux in the 
      control period but not during glucose infusion, suggesting a glycogen-sparing 
      effect. Arterial concentrations and net cardiac fluxes of oxygen, glutamate, and 
      alanine remained unaltered. In conclusion, beneficial effects of glucose during 
      ischemia are associated with increased aerobic and anaerobic glycolysis, saving 
      of glycogen, and decreased lipolysis.
FAU - Thomassen, A
AU  - Thomassen A
AD  - Department of Cardiology, Skejby Sygehus, Aarhus N. Denmark.
FAU - Nielsen, T T
AU  - Nielsen TT
FAU - Bagger, J P
AU  - Bagger JP
FAU - Henningsen, P
AU  - Henningsen P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 0 (Blood Glucose)
RN  - 0 (Citrates)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Glutamates)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - IY9XDZ35W2 (Glucose)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Alanine/blood
MH  - Angina Pectoris/metabolism/*prevention & control
MH  - Blood Glucose/analysis
MH  - *Cardiac Pacing, Artificial
MH  - Citrates/blood
MH  - Coronary Disease/blood/*metabolism/physiopathology
MH  - Electrocardiography
MH  - Fatty Acids, Nonesterified/blood
MH  - Female
MH  - Glucose/*administration & dosage/metabolism
MH  - Glutamates/blood
MH  - Humans
MH  - Infusions, Intravenous
MH  - Insulin/blood
MH  - Lactates/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*metabolism
MH  - Oxygen Consumption/drug effects
EDAT- 1989/07/01 00:00
MHDA- 1989/07/01 00:01
CRDT- 1989/07/01 00:00
PHST- 1989/07/01 00:00 [pubmed]
PHST- 1989/07/01 00:01 [medline]
PHST- 1989/07/01 00:00 [entrez]
AID - 0002-8703(89)90067-7 [pii]
AID - 10.1016/0002-8703(89)90067-7 [doi]
PST - ppublish
SO  - Am Heart J. 1989 Jul;118(1):25-32. doi: 10.1016/0002-8703(89)90067-7.