PMID- 26628882
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151202
LR  - 20181113
IS  - 1198-0052 (Print)
IS  - 1718-7729 (Electronic)
IS  - 1198-0052 (Linking)
VI  - 22
IP  - 5
DP  - 2015 Oct
TI  - A primary intravascular synovial sarcoma causing deep-vein thrombosis and 
      pulmonary embolism in a 20-year-old woman.
PG  - e387-90
LID - 10.3747/co.22.2315 [doi]
AB  - Primary intravascular synovial sarcoma is a rare malignancy with only a few cases 
      documented in the literature. On presentation, this tumour usually resembles a 
      deep venous thrombosis (dvt) or pulmonary embolism (pe). Here, we report the case 
      of a 20-year-old woman complaining of shortness of breath who had a history of 
      dvt 6 weeks before presentation at our institution. Vascular ultrasound detected 
      a suspicious mass in the right groin, which was identified as a monophasic 
      synovial sarcoma by surgical biopsy. The tumour extended from the right 
      superficial femoral vein into the common iliac vein, profound femoral vein, and 
      great saphenous vein. It caused pe with near-total occlusion of the right 
      pulmonary artery. After initial treatment on the cardiac intensive care unit, the 
      patient was referred to the oncology department for neoadjuvant radiochemotherapy 
      with doxorubicin-ifosfamide according to the Interdisziplinare 
      Arbeitsgemeinschaft Weichteilsarkome [Interdisciplinary AG Sarcomas] protocol and 
      surgical resection of the tumour. No signs of tumour recurrence were found during 
      the subsequent course of the disease, but the patient died from treatment 
      complications approximately 15 months after initial presentation. This case 
      underlines the importance of screening for malignancies even in young patients 
      presenting with dvt or pe. We also recommend whole-leg compression 
      ultrasonography in patients with suspected dvt or pe (as opposed to venography or 
      simple four-point ultrasound examination in the groin and popliteal fossa) to 
      detect possible underlying causes for thrombosis.
FAU - Schreiner, M
AU  - Schreiner M
AD  - Department of Internal Medicine, Cardiology and Angiology, 
      Charite-Universitatsmedizin Berlin, Berlin, Germany; ; Department of Internal 
      Medicine, Bundeswehr Hospital, Berlin, Germany;
FAU - Sanad, W
AU  - Sanad W
AD  - Department of Internal Medicine, Cardiology and Angiology, 
      Charite-Universitatsmedizin Berlin, Berlin, Germany;
FAU - Pfitzner, B M
AU  - Pfitzner BM
AD  - Pathology Institute, Charite-Universitatsmedizin Berlin, Berlin, Germany.
FAU - Baumann, G
AU  - Baumann G
AD  - Department of Internal Medicine, Cardiology and Angiology, 
      Charite-Universitatsmedizin Berlin, Berlin, Germany;
FAU - Knebel, F
AU  - Knebel F
AD  - Department of Internal Medicine, Cardiology and Angiology, 
      Charite-Universitatsmedizin Berlin, Berlin, Germany;
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Curr Oncol
JT  - Current oncology (Toronto, Ont.)
JID - 9502503
PMC - PMC4608415
OTO - NOTNLM
OT  - Synovial sarcoma
OT  - deep-vein thrombosis
OT  - intravascular tumours
OT  - pulmonary embolism
EDAT- 2015/12/03 06:00
MHDA- 2015/12/03 06:01
PMCR- 2015/10/01
CRDT- 2015/12/03 06:00
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2015/12/03 06:01 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - conc-22-e387 [pii]
AID - 10.3747/co.22.2315 [doi]
PST - ppublish
SO  - Curr Oncol. 2015 Oct;22(5):e387-90. doi: 10.3747/co.22.2315.