PMID- 26628963
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151202
LR  - 20200929
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 9
DP  - 2015
TI  - Sevoflurane inhibits the phosphorylation of ribosomal protein S6 in neonatal rat 
      brain.
PG  - 14816-26
AB  - Besides neurotoxic effects, inhaled anesthetics might have other adverse effects 
      on the developing brain. Ribosomal protein S6 (rpS6), the first identified 
      ribosomal protein undergoing phosphorylation, has important physiological 
      functions in regulating protein synthesis, cell proliferation, and glucose 
      homeostasis. To date, the function of sevoflurane on rpS6 phosphorylation is 
      unclear. In our present study, we showed that sevoflurane anesthesia inhibited 
      rpS6 phosphorylation in cerebral cortex and CA1 region of the hippocampus. The 
      activity of Akt was detected to be reduced within both cortical and hippocampal 
      regions in the brain with the treatment of sevoflurane. However, the treatment 
      seemed to have no effect on the phosphorylation of mammalian target of rapamycin 
      (mTOR), a downstream effector of Akt. Sevoflurane had a paradoxical effect on ERK 
      activity in the hippocampus and cerebral cortex. Last but not the least, 
      Sevoflurane increased PP1 activity in the cerebral cortex and hippocampus. Thus, 
      the exposure to sevoflurane inhibited dramatically the phosphorylation of rpS6 in 
      neonatal rat brains. The inhibitory effect of sevoflurane on rpS6 phosphorylation 
      might be mediated by the suppression on AKT activity at an mTOR-independent 
      manner and the enhancement of PP1 activity.
FAU - Tan, Hong
AU  - Tan H
AD  - Department of Anesthesia and Critical Care, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
FAU - Li, Chang-Lin
AU  - Li CL
AD  - Department of Anesthesia and Critical Care, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - Department of Anesthesia and Critical Care, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
FAU - Yang, Zhou-Jing
AU  - Yang ZJ
AD  - Department of Anesthesia and Critical Care, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
FAU - Zhao, Xuan
AU  - Zhao X
AD  - Department of Anesthesia and Critical Care, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
FAU - Wang, Ying-Wei
AU  - Wang YW
AD  - Department of Anesthesia and Critical Care, Xinhua Hospital, Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20150915
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4658852
OTO - NOTNLM
OT  - Sevoflurane
OT  - cerebral cortex
OT  - hippocampus
OT  - ribosomal protein S6
EDAT- 2015/12/03 06:00
MHDA- 2015/12/03 06:01
PMCR- 2015/09/15
CRDT- 2015/12/03 06:00
PHST- 2015/08/16 00:00 [received]
PHST- 2015/08/25 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2015/12/03 06:01 [medline]
PHST- 2015/09/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Sep 15;8(9):14816-26. eCollection 2015.