PMID- 26629000
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151202
LR  - 20200929
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 9
DP  - 2015
TI  - Determination of xanthotoxin using a liquid chromatography-mass spectrometry and 
      its application to pharmacokinetics and tissue distribution model in rat.
PG  - 15164-72
AB  - A simple and selective liquid chromatography mass spectrometry method for 
      determination of xanthotoxin in rat plasma and various tissues for 
      pharmacokinetic was developed. Chromatographic separation was achieved on a C18 
      (2.1 mm x 150 mm, 5 mum) column with acetonitrile-0.1% formic acid in water as 
      mobile phase with gradient elution. An electrospray ionization source was applied 
      and operated in positive ion mode; selective ion monitoring (SIM) mode was used 
      for quantification using target fragment ions m/z 217 for xanthotoxin and m/z 326 
      for the internal standard. The resulting calibration curves offered satisfactory 
      linearity (R(2) > 0.99) within the test range. Mean recoveries of xanthotoxin in 
      rat plasma were in the range of 79.9%-84.6%. RSD of intra-day and inter-day 
      precision were both < 14%. The accuracy of the method ranged from 87.5% to 
      109.8%. The assay was successfully applied to the pharmacokinetics and tissue 
      distribution model studies of xanthotoxin in rats. The oral bioavailability of 
      xanthotoxin was 73.2% in rats.
FAU - Tian, Weiqiang
AU  - Tian W
AD  - Department of Pharmacy, Lishui Central Hospital Lishui 323000, China.
FAU - Cai, Jinzhang
AU  - Cai J
AD  - The Second Affiliated & Yuying Children's Hospital Wenzhou Medical University 
      Wenzhou 325000, China.
FAU - Xu, Yanyan
AU  - Xu Y
AD  - Department of Pharmacy, Lishui Central Hospital Lishui 323000, China.
FAU - Luo, Xinhua
AU  - Luo X
AD  - Department of Clinical Lab Medicine, Taizhou Municipal Hospital Affiliated with 
      Taizhou University Taizhou 331000, China.
FAU - Zhang, Jin
AU  - Zhang J
AD  - Department of Clinical Lab Medicine, Taizhou Municipal Hospital Affiliated with 
      Taizhou University Taizhou 331000, China.
FAU - Zhang, Zixue
AU  - Zhang Z
AD  - Shanghai Institute of Pharmaceutical Industry Shanghai 200437, China.
FAU - Zhang, Qingwei
AU  - Zhang Q
AD  - Shanghai Institute of Pharmaceutical Industry Shanghai 200437, China.
FAU - Wang, Xianqin
AU  - Wang X
AD  - The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325035, 
      China.
FAU - Hu, Lufeng
AU  - Hu L
AD  - The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325035, 
      China.
FAU - Lin, Guanyang
AU  - Lin G
AD  - The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325035, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20150915
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4658889
OTO - NOTNLM
OT  - Xanthotoxin
OT  - determination
OT  - pharmacokinetics
OT  - tissue distribution
EDAT- 2015/12/03 06:00
MHDA- 2015/12/03 06:01
PMCR- 2015/09/15
CRDT- 2015/12/03 06:00
PHST- 2015/07/03 00:00 [received]
PHST- 2015/09/05 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2015/12/03 06:01 [medline]
PHST- 2015/09/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Sep 15;8(9):15164-72. eCollection 2015.