PMID- 26629022
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151202
LR  - 20201216
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 9
DP  - 2015
TI  - Association between resting heart rate and cardiovascular mortality: evidence 
      from a meta-analysis of prospective studies.
PG  - 15329-39
AB  - The results from published studies on resting heart rate (RHR) and risk of 
      cardiovascular mortality are not consistent. We therefore conducted a 
      meta-analysis to quantitatively summarize the evidence from prospective studies 
      about the association of RHR with risk cardiovascular mortality. Pertinent 
      studies were identified by a search of Pubmed and Web of Knowledge to January 
      2015. The random effect model was used. Sensitivity analysis and publication bias 
      were conducted. Dose-response relationship was assessed by restricted cubic 
      spline and variance-weighted least squares regression analysis. Twenty 
      prospective articles were included in this meta-analysis. Pooled results 
      suggested that highest RHR level versus lowest levels was significantly 
      associated with the risk of cardiovascular mortality [summary relative risk (RR) 
      = 1.69, 95% CI = 1.42-2.00, I(2) = 87.5%]. Subjects with RHR levels of > 80 bites 
      per minute (bpm) had a RR of 1.49 (1.24-1.79) for cardiovascular mortality. The 
      results for subgroups analysis of geographic locations, sex and duration of 
      follow-up are consistent with the overall results. The linear dose-response 
      analysis indicated that an increase in RHR of 10 bpm was statistically 
      significantly associated with a 6% increase in the risk of developing 
      cardiovascular mortality (summary RR = 1.06, 95% CI = 1.04-1.08). Thus, we 
      conclude that elevated RHR was significantly associated with an increased risk of 
      cardiovascular mortality.
FAU - Li, Yuechun
AU  - Li Y
AD  - Department of Cardiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong 
      University School of Medicine Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20150915
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4658911
OTO - NOTNLM
OT  - Resting heart rate
OT  - cardiovascular mortality
OT  - meta-analysis
EDAT- 2015/12/03 06:00
MHDA- 2015/12/03 06:01
PMCR- 2015/09/15
CRDT- 2015/12/03 06:00
PHST- 2015/04/13 00:00 [received]
PHST- 2015/09/06 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2015/12/03 06:01 [medline]
PHST- 2015/09/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Sep 15;8(9):15329-39. eCollection 2015.