PMID- 26629352
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151202
LR  - 20220408
IS  - 2053-8790 (Print)
IS  - 2053-8790 (Electronic)
IS  - 2053-8790 (Linking)
VI  - 2
IP  - 1
DP  - 2015
TI  - A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best 
      predicts long-term renal outcome in lupus nephritis: data from the MAINTAIN 
      Nephritis Trial.
PG  - e000123
LID - 10.1136/lupus-2015-000123 [doi]
LID - e000123
AB  - BACKGROUND: Although an early decrease in proteinuria has been correlated with 
      good long-term renal outcome in lupus nephritis (LN), studies aimed at defining a 
      cut-off proteinuria value are missing, except a recent analysis performed on 
      patients randomised in the Euro-Lupus Nephritis Trial, demonstrating that a 
      target value of 0.8 g/day at month 12 optimised sensitivity and specificity for 
      the prediction of good renal outcome. The objective of the current work is to 
      validate this target in another LN study, namely the MAINTAIN Nephritis Trial 
      (MNT). METHODS: Long-term (at least 7 years) renal function data were available 
      for 90 patients randomised in the MNT. Receiver operating characteristic curves 
      were built to test the performance of proteinuria measured within the 1st year as 
      short-term predictor of long-term renal outcome. We calculated the positive and 
      negative predictive values (PPV, NPV). RESULTS: After 12 months of treatment, 
      achievement of a proteinuria <0.7 g/day best predicted good renal outcome, with a 
      sensitivity and a specificity of 71% and 75%, respectively. The PPV was high 
      (94%) but the NPV low (29%). Addition of the requirement of urine red blood cells 
      </=5/hpf as response criteria at month 12 reduced sensitivity from 71% to 41%. 
      CONCLUSIONS: In this cohort of mainly Caucasian patients suffering from a first 
      episode of LN in most cases, achievement of a proteinuria <0.7 g/day at month 12 
      best predicts good outcome at 7 years and inclusion of haematuria in the set of 
      criteria at month 12 undermines the sensitivity of early proteinuria decrease for 
      the prediction of good outcome. The robustness of these conclusions stems from 
      the very similar results obtained in two distinct LN cohorts. TRIAL REGISTRATION 
      NUMBER: NCT00204022.
FAU - Tamirou, Farah
AU  - Tamirou F
AD  - Rheumatology Department , Cliniques Universitaires Saint-Luc, Pole de Pathologies 
      Rhumatismales Inflammatoires et Systemiques, Universite catholique de Louvain , 
      Bruxelles , Belgium.
FAU - Lauwerys, Bernard R
AU  - Lauwerys BR
AD  - Rheumatology Department , Cliniques Universitaires Saint-Luc, Pole de Pathologies 
      Rhumatismales Inflammatoires et Systemiques, Universite catholique de Louvain , 
      Bruxelles , Belgium.
FAU - Dall'Era, Maria
AU  - Dall'Era M
AD  - Division of Rheumatology , Russell/Engelman Research Center, University of 
      California, San Francisco , San Francisco, California , USA.
FAU - Mackay, Meggan
AU  - Mackay M
AD  - The Feinstein Institute for Medical Research , Manhasset, New York , USA.
FAU - Rovin, Brad
AU  - Rovin B
AD  - Ohio State University, Wexner Medical Center , Columbus, Ohio , USA.
FAU - Cervera, Ricard
AU  - Cervera R
AD  - Department of Autoimmune Diseases , Hospital Clinic, Universitat de Barcelona , 
      Barcelona, Catalonia , Spain.
FAU - Houssiau, Frederic A
AU  - Houssiau FA
AD  - Rheumatology Department , Cliniques Universitaires Saint-Luc, Pole de Pathologies 
      Rhumatismales Inflammatoires et Systemiques, Universite catholique de Louvain , 
      Bruxelles , Belgium.
CN  - MAINTAIN Nephritis Trial Investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT00204022
PT  - Journal Article
DEP - 20151112
PL  - England
TA  - Lupus Sci Med
JT  - Lupus science & medicine
JID - 101633705
PMC - PMC4654096
OTO - NOTNLM
OT  - Lupus Nephritis
OT  - Outcomes research
OT  - proteinuria
FIR - Abramowicz, Daniel
IR  - Abramowicz D
FIR - Atzeni, Fabiola
IR  - Atzeni F
FIR - Blockmans, Daniel
IR  - Blockmans D
FIR - Danieli, Maria Giovanna
IR  - Danieli MG
FIR - De Clercq, Luc
IR  - De Clercq L
FIR - D'Cruz, David
IR  - D'Cruz D
FIR - Ayala Guttierez, Maria del Mar
IR  - Ayala Guttierez Mdel M
FIR - Garrido, Enrique de Ramon
IR  - Garrido Ede R
FIR - Gilboe, Inge-Magrethe
IR  - Gilboe IM
FIR - de Keyser, Filip
IR  - de Keyser F
FIR - Delahousse, Michel
IR  - Delahousse M
FIR - Espinosa, Gerard
IR  - Espinosa G
FIR - Fiehn, Christoph
IR  - Fiehn C
FIR - Golstein, Marc
IR  - Golstein M
FIR - Guillevin, Loic
IR  - Guillevin L
FIR - Hirsch, Marco
IR  - Hirsch M
FIR - Karras, Alexandre
IR  - Karras A
FIR - Lang, Philippe
IR  - Lang P
FIR - le Guern, Veronique
IR  - le Guern V
FIR - Marchal, Martine
IR  - Marchal M
FIR - Marinho, Antonio
IR  - Marinho A
FIR - Max, Regina
IR  - Max R
FIR - Peeters, Patrick
IR  - Peeters P
FIR - Petera, Peter
IR  - Petera P
FIR - Petrovic, Radmila
IR  - Petrovic R
FIR - Quemeneur, Thomas
IR  - Quemeneur T
FIR - Raeman, Frank
IR  - Raeman F
FIR - Remy, Philippe
IR  - Remy P
FIR - Ravelingien, Isabelle
IR  - Ravelingien I
FIR - Sarzi-Puttini, Piercarlo
IR  - Sarzi-Puttini P
FIR - Sangle, Shirish
IR  - Sangle S
FIR - Tektonidou, Maria
IR  - Tektonidou M
FIR - Valiente de Santis, Lucia
IR  - Valiente de Santis L
FIR - Vasconcelos, Carlos
IR  - Vasconcelos C
FIR - Verresen, Luc
IR  - Verresen L
FIR - Weiss, Laurence
IR  - Weiss L
FIR - Westhovens, Rene
IR  - Westhovens R
EDAT- 2015/12/03 06:00
MHDA- 2015/12/03 06:01
PMCR- 2015/11/12
CRDT- 2015/12/03 06:00
PHST- 2015/09/04 00:00 [received]
PHST- 2015/10/06 00:00 [revised]
PHST- 2015/10/10 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2015/12/03 06:01 [medline]
PHST- 2015/11/12 00:00 [pmc-release]
AID - lupus-2015-000123 [pii]
AID - 10.1136/lupus-2015-000123 [doi]
PST - epublish
SO  - Lupus Sci Med. 2015 Nov 12;2(1):e000123. doi: 10.1136/lupus-2015-000123. 
      eCollection 2015.