PMID- 26629642
OWN - NLM
STAT- MEDLINE
DCOM- 20161013
LR  - 20161230
IS  - 1439-0795 (Electronic)
IS  - 0176-3679 (Linking)
VI  - 49
IP  - 1
DP  - 2016 Jan
TI  - Elevated Rest Heart Rate in Psychiatric Patients and Different Effects of 
      Psychotropic Medication.
PG  - 18-22
LID - 10.1055/s-0035-1565204 [doi]
AB  - INTRODUCTION: Elevated rest heart rate (RHR) is a known risk factor of 
      cardiovascular diseases. The aim of this study was to analyse the effects of 
      different psychiatric disorders and psychotropic medication on RHR. METHODS: In 
      this retrospective study, medical records of 590 inpatients with a psychiatric 
      disorder (309 men, 281 women, mean age 42.11; SD=13.8 years) were evaluated. RHR, 
      the psychiatric diagnosis according to ICD-10, the psychotropic medication and 
      the use of beta blockers were assessed. RESULTS: The average RHR of all patients 
      was 85.62 beats per minute (bpm) (SD=10.60 bpm) which is, according to the 
      literature and the consensus of experts, to be considered as a relevant elevation 
      of RHR. There was a significant negative correlation between age and RHR. 
      Patients treated with monotherapy or with SSRI showed in the multiple regression 
      analysis significant lower RHR than other subjects, whereas both polytherapy with 
      more antipsychotics and the diagnosis of schizophrenia could be identified as an 
      independent risk factor of elevated RHR (p<0.05, 2-tailed). The presence of 
      hypertonia, diabetes, hypercholesterolemia or obesity has no influence on RHR. 6% 
      of the study population received beta blocker during the hospitalization. 
      DISCUSSION: The elevated RHR in psychiatric patients is a common phenomenon and 
      can be observed independently of the use of psychotropic medication but more in 
      patients with schizophrenia. An interesting additional finding could be a 
      possible protective effect of SSRI on RHR in psychiatric patients.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Sarlon, J
AU  - Sarlon J
AD  - Department of Psychiatry, University Hospital Frankfurt am Main, Germany.
FAU - Habich, O
AU  - Habich O
AD  - Department of Internal and Geriatric Medicine, Diakonissen Hospital Frankfurt am 
      Main, Germany.
FAU - Schneider, B
AU  - Schneider B
AD  - Department of Addictive Disorders, Landschaftsverband Rheinland Clinic Cologne, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20151202
PL  - Germany
TA  - Pharmacopsychiatry
JT  - Pharmacopsychiatry
JID - 8402938
RN  - 0 (Psychotropic Drugs)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blood Pressure/drug effects
MH  - Female
MH  - Heart Rate/*drug effects
MH  - Humans
MH  - Male
MH  - Mental Disorders/drug therapy
MH  - Middle Aged
MH  - Psychotropic Drugs/*adverse effects/*pharmacology/therapeutic use
MH  - Regression Analysis
MH  - *Rest
MH  - Young Adult
EDAT- 2015/12/03 06:00
MHDA- 2016/10/14 06:00
CRDT- 2015/12/03 06:00
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/10/14 06:00 [medline]
AID - 10.1055/s-0035-1565204 [doi]
PST - ppublish
SO  - Pharmacopsychiatry. 2016 Jan;49(1):18-22. doi: 10.1055/s-0035-1565204. Epub 2015 
      Dec 2.