PMID- 26630405
OWN - NLM
STAT- MEDLINE
DCOM- 20161114
LR  - 20180618
IS  - 2238-0019 (Electronic)
IS  - 2237-6089 (Linking)
VI  - 37
IP  - 3
DP  - 2015 Jul-Sep
TI  - Ethanol during adolescence decreased the BDNF levels in the hippocampus in adult 
      male Wistar rats, but did not alter aggressive and anxiety-like behaviors.
PG  - 143-51
LID - S2237-60892015000300143 [pii]
LID - 10.1590/2237-6089-2015-0017 [doi]
AB  - OBJECTIVE: To investigate the effects of ethanol exposure in adolescent rats 
      during adulthood by assesssing aggression and anxiety-like behaviors and 
      measuring the levels of inflammatory markers. METHODS: Groups of male Wistar rats 
      (mean weight 81.4 g, n = 36) were housed in groups of four until postnatal day 
      (PND) 60. From PNDs 30 to 46, rats received one of three treatments: 3 g/kg of 
      ethanol (15% w/v, orally, n = 16), 1.5 g/kg of ethanol (12.5% w/v, PO, n = 12), 
      or water (n = 12) every 48 hours. Animals were assessed for aggressive behavior 
      (resident x intruder test) and anxiety-like behaviors (elevated plus maze) during 
      adulthood. RESULTS: Animals that received low doses of alcohol showed reduced 
      levels of brain-derived neurotrophic factor (BDNF) in the hippocampus as compared 
      to the control group. No significant difference was found in prefrontal cortex. 
      CONCLUSIONS: Intermittent exposure to alcohol during adolescence is associated 
      with lower levels of BDNF in the hippocampus, probably due the episodic 
      administration of alcohol, but alcohol use did not alter the level agression 
      toward a male intruder or anxiety-like behaviors during the adult phase.
FAU - Scheidt, Leticia
AU  - Scheidt L
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
FAU - Fries, Gabriel Rodrigo
AU  - Fries GR
AD  - Hospital de Clinicas de Porto Alegre, UFRGS, Porto Alegre, RS, Brazil.
FAU - Stertz, Laura
AU  - Stertz L
AD  - Hospital de Clinicas de Porto Alegre, UFRGS, Porto Alegre, RS, Brazil.
FAU - Cabral, Joao Carlos Centurion
AU  - Cabral JC
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
AD  - Hospital de Clinicas de Porto Alegre, UFRGS, Porto Alegre, RS, Brazil.
FAU - de Almeida, Rosa Maria Martins
AU  - de Almeida RM
AD  - Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Trends Psychiatry Psychother
JT  - Trends in psychiatry and psychotherapy
JID - 101610695
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Interleukin-1alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Aggression/drug effects/physiology/psychology
MH  - Animals
MH  - Anxiety/physiopathology
MH  - Binge Drinking/*metabolism/*psychology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Central Nervous System Depressants/*administration & dosage/adverse effects
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/*administration & dosage/adverse effects
MH  - Hippocampus/*drug effects/*growth & development/metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukin-1alpha/metabolism
MH  - Male
MH  - Prefrontal Cortex/drug effects/growth & development/metabolism
MH  - Rats, Wistar
MH  - Risk-Taking
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2015/12/03 06:00
MHDA- 2016/11/15 06:00
CRDT- 2015/12/03 06:00
PHST- 2015/03/25 00:00 [received]
PHST- 2015/07/21 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/11/15 06:00 [medline]
AID - S2237-60892015000300143 [pii]
AID - 10.1590/2237-6089-2015-0017 [doi]
PST - ppublish
SO  - Trends Psychiatry Psychother. 2015 Jul-Sep;37(3):143-51. doi: 
      10.1590/2237-6089-2015-0017.