PMID- 26630485
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 12
DP  - 2015
TI  - The Relationship between Cortisol Activity during Cognitive Task and 
      Posttraumatic Stress Symptom Clusters.
PG  - e0144315
LID - 10.1371/journal.pone.0144315 [doi]
LID - e0144315
AB  - BACKGROUND: The latest development in the dimensional structure of posttraumatic 
      stress disorder (PTSD) is a novel 6-factor model, which builds on the newly 
      released DSM-5. One notable gap in the literature is that little is known about 
      how distinct symptom clusters of PTSD are related to 
      hypothalamic-pituitary-adrenal (HPA) axis activity when people perform a 
      relatively less stressful cognitive task. The purpose of this study was to 
      investigate the relationship between cortisol activity when individuals perform 
      cognitive tasks in the laboratory and a contemporary phenotypic model of 
      posttraumatic stress symptomatology in earthquake survivors. METHODS: Salivary 
      cortisol while performing cognitive tasks was collected and analyzed in 89 adult 
      earthquake survivors. The PTSD Checklist for the DSM-5 (PCL-5) was used to assess 
      the severity of total PTSD as well as six distinct symptom clusters. Regression 
      analyses were conducted to examine the associations between the six distinct PTSD 
      symptom clusters and cortisol profiles. RESULTS: The results showed that the 
      score of the negative affect symptom cluster, but not anhedonia or other 
      clusters, was positively associated with cortisol levels before and during the 
      cognitive tasks. CONCLUSION: The results showed that higher cortisol levels 
      before and during cognitive tasks might be specifically linked to a distinct 
      symptom cluster of PTSD-negative affect symptomatology. This suggests that a 
      distinction should be made between negative affect and anhedonia symptom 
      clusters, as the 6-factor model proposed.
FAU - Duan, Hongxia
AU  - Duan H
AD  - Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Wang, Li
AU  - Wang L
AD  - Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Zhang, Liang
AU  - Zhang L
AD  - Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Zhang, Kan
AU  - Zhang K
AD  - Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
FAU - Wu, Jianhui
AU  - Wu J
AD  - Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of 
      Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151202
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anhedonia/physiology
MH  - Checklist/methods
MH  - Cognition/*physiology
MH  - Earthquakes
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*metabolism
MH  - Hypothalamo-Hypophyseal System/metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pituitary-Adrenal System/physiopathology
MH  - Stress Disorders, Post-Traumatic/*metabolism/*physiopathology
MH  - Survivors/*psychology
MH  - Syndrome
MH  - Young Adult
PMC - PMC4667843
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/12/03 06:00
MHDA- 2016/06/21 06:00
PMCR- 2015/12/02
CRDT- 2015/12/03 06:00
PHST- 2015/08/20 00:00 [received]
PHST- 2015/11/16 00:00 [accepted]
PHST- 2015/12/03 06:00 [entrez]
PHST- 2015/12/03 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
PHST- 2015/12/02 00:00 [pmc-release]
AID - PONE-D-15-36636 [pii]
AID - 10.1371/journal.pone.0144315 [doi]
PST - epublish
SO  - PLoS One. 2015 Dec 2;10(12):e0144315. doi: 10.1371/journal.pone.0144315. 
      eCollection 2015.