PMID- 26631135
OWN - NLM
STAT- MEDLINE
DCOM- 20170322
LR  - 20181113
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 254
IP  - 5
DP  - 2016 May
TI  - Early macular ganglion cell-inner plexiform layer analysis in non-arteritic 
      anterior ischemic optic neuropathy.
PG  - 983-9
LID - 10.1007/s00417-015-3230-9 [doi]
AB  - PURPOSE: To investigate the potential usefulness of early macular ganglion 
      cell-inner plexiform layer (mGCIPL) measurement for detecting retinal ganglion 
      cell damage in eyes with non-arteritic anterior ischemic optic neuropathy 
      (NAION). METHODS: Thirteen patients with NAION were examined within 1 month of 
      visual disturbance onset and underwent spectral domain optical coherence 
      tomography (SD-OCT) measurement of the mGCIPL and peripapillary retinal nerve 
      fiber layer (pRNFL). Complete ophthalmologic evaluations, including visual acuity 
      and visual field (VF) test, were performed. The time to minimum and average 
      mGCIPL and pRNFL thinning were investigated. The correlation between the area of 
      mGCIPL thinning and the affected VF area was also analyzed. RESULTS: Thirteen 
      eyes of 13 patients with NAION were included. The length of time from visual 
      disturbance onset to minimum and average mGCIPL thinning was 32.5 +/- 12.1 days and 
      46.1 +/- 23.2 days, respectively, and the time to pRNFL thinning was 
      79.2 +/- 19.7 days. There was a significant regional correlation between the area 
      of mGCIPL loss and that of the VF defect in the early phase (r = 0.610; 
      p = 0.027). However, the area of mGCIPL thinning in the late phase did not 
      correlate with that of late VF defects. CONCLUSIONS: In the early phase, mGCIPL 
      thinning was observed, and the area of mGCIPL thinning correlated with that of 
      the VF defect in eyes with NAION. Therefore, early retinal ganglion cell damage 
      and dysfunction may be detected in NAION by measurement of mGCIPL using SD-OCT.
FAU - Park, Sang Woo
AU  - Park SW
AD  - Department of Ophthalmology, Chonnam National University Medical School and 
      Hospital, #8 Hak-dong, Dong-gu, Gwangju, 501-757, South Korea.
FAU - Ji, Yong Sok
AU  - Ji YS
AD  - Department of Ophthalmology, Chonnam National University Medical School and 
      Hospital, #8 Hak-dong, Dong-gu, Gwangju, 501-757, South Korea.
FAU - Heo, Hwan
AU  - Heo H
AD  - Department of Ophthalmology, Chonnam National University Medical School and 
      Hospital, #8 Hak-dong, Dong-gu, Gwangju, 501-757, South Korea. 
      opheye@hanmail.net.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20151203
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arteritis/diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/pathology
MH  - Optic Neuropathy, Ischemic/*diagnosis
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Vision Disorders/diagnosis
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
MH  - Visual Fields/physiology
OTO - NOTNLM
OT  - Macular ganglion cell layer
OT  - Non-arteritic anterior ischemic optic neuropathy
OT  - Optical coherence tomography
EDAT- 2015/12/04 06:00
MHDA- 2017/03/23 06:00
CRDT- 2015/12/04 06:00
PHST- 2015/06/16 00:00 [received]
PHST- 2015/11/24 00:00 [accepted]
PHST- 2015/11/18 00:00 [revised]
PHST- 2015/12/04 06:00 [entrez]
PHST- 2015/12/04 06:00 [pubmed]
PHST- 2017/03/23 06:00 [medline]
AID - 10.1007/s00417-015-3230-9 [pii]
AID - 10.1007/s00417-015-3230-9 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2016 May;254(5):983-9. doi: 
      10.1007/s00417-015-3230-9. Epub 2015 Dec 3.