PMID- 26631814
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20191210
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 126
DP  - 2016 Feb 1
TI  - Entorhinal volume, aerobic fitness, and recognition memory in healthy young 
      adults: A voxel-based morphometry study.
PG  - 229-38
LID - S1053-8119(15)01071-X [pii]
LID - 10.1016/j.neuroimage.2015.11.049 [doi]
AB  - Converging evidence supports the hypothesis effects of aerobic exercise and 
      environmental enrichment are beneficial for cognition, in particular for 
      hippocampus-supported learning and memory. Recent work in humans suggests that 
      exercise training induces changes in hippocampal volume, but it is not known if 
      aerobic exercise and fitness also impact the entorhinal cortex. In animal models, 
      aerobic exercise increases expression of growth factors, including brain derived 
      neurotrophic factor (BDNF). This exercise-enhanced expression of growth hormones 
      may boost synaptic plasticity, and neuronal survival and differentiation, 
      potentially supporting function and structure in brain areas including but not 
      limited to the hippocampus. Here, using voxel based morphometry and a standard 
      graded treadmill test to determine cardio-respiratory fitness (Bruce protocol; 
      .VO2 max), we examined if entorhinal and hippocampal volumes were associated with 
      cardio-respiratory fitness in healthy young adults (N=33). In addition, we 
      examined if volumes were modulated by recognition memory performance and by serum 
      BDNF, a putative marker of synaptic plasticity. Our results show a positive 
      association between volume in right entorhinal cortex and cardio-respiratory 
      fitness. In addition, average gray matter volume in the entorhinal cortex, 
      bilaterally, was positively associated with memory performance. These data extend 
      prior work on the cerebral effects of aerobic exercise and fitness to the 
      entorhinal cortex in healthy young adults thus providing compelling evidence for 
      a relationship between aerobic fitness and structure of the medial temporal lobe 
      memory system.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Whiteman, Andrew S
AU  - Whiteman AS
AD  - Dept. of Psychological and Brain Sciences, Boston Univ., 2 Cummington Mall, 
      Boston, MA 02215, USA; Center for Memory and Brain, Boston Univ., 2 Cummington 
      Mall, Boston, MA 02215, USA. Electronic address: asw221@bu.edu.
FAU - Young, Daniel E
AU  - Young DE
AD  - College of Nursing and Health Sciences, Exercise and Health Sciences Program, 
      Univ. of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA. 
      Electronic address: daniel.young@umb.edu.
FAU - Budson, Andrew E
AU  - Budson AE
AD  - Dept. of Neurology, Boston Univ. School of Medicine, Boston, MA, USA; VA Boston 
      Healthcare System, 150 South Huntington St., Boston, MA 02130, USA. Electronic 
      address: abudson@bu.edu.
FAU - Stern, Chantal E
AU  - Stern CE
AD  - Dept. of Psychological and Brain Sciences, Boston Univ., 2 Cummington Mall, 
      Boston, MA 02215, USA; Center for Memory and Brain, Boston Univ., 2 Cummington 
      Mall, Boston, MA 02215, USA. Electronic address: chantal@bu.edu.
FAU - Schon, Karin
AU  - Schon K
AD  - Dept. of Psychological and Brain Sciences, Boston Univ., 2 Cummington Mall, 
      Boston, MA 02215, USA; Center for Memory and Brain, Boston Univ., 2 Cummington 
      Mall, Boston, MA 02215, USA; Dept. of Anatomy and Neurobiology, Boston Univ. 
      School of Medicine, 72 East Concord St., Boston, MA, USA; Center for Biomedical 
      Imaging, Boston Univ. School of Medicine, 650 Albany Street, Boston, MA, USA. 
      Electronic address: kschon@bu.edu.
LA  - eng
GR  - K99 AG036845/AG/NIA NIH HHS/United States
GR  - R00AG036845/AG/NIA NIH HHS/United States
GR  - UL1 TR000157/TR/NCATS NIH HHS/United States
GR  - UL1-TR000157/TR/NCATS NIH HHS/United States
GR  - R00 AG036845/AG/NIA NIH HHS/United States
GR  - K99AG036845/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20151126
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Entorhinal Cortex/*anatomy & histology
MH  - Exercise Test
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Physical Fitness/*physiology
MH  - Recognition, Psychology/*physiology
MH  - Young Adult
PMC - PMC4733633
MID - NIHMS744066
OTO - NOTNLM
OT  - Cardiovascular fitness
OT  - Hippocampus
OT  - Medial temporal lobes
OT  - Neurotrophins
OT  - Recognition memory
EDAT- 2015/12/04 06:00
MHDA- 2016/12/15 06:00
PMCR- 2017/02/01
CRDT- 2015/12/04 06:00
PHST- 2015/07/14 00:00 [received]
PHST- 2015/11/18 00:00 [revised]
PHST- 2015/11/20 00:00 [accepted]
PHST- 2015/12/04 06:00 [entrez]
PHST- 2015/12/04 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - S1053-8119(15)01071-X [pii]
AID - 10.1016/j.neuroimage.2015.11.049 [doi]
PST - ppublish
SO  - Neuroimage. 2016 Feb 1;126:229-38. doi: 10.1016/j.neuroimage.2015.11.049. Epub 
      2015 Nov 26.