PMID- 26632725
OWN - NLM
STAT- MEDLINE
DCOM- 20160418
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 94
IP  - 47
DP  - 2015 Nov
TI  - Tubulointerstitial Nephritis and Uveitis Syndrome in an Elderly Man: Case Report 
      and Literature Review.
PG  - e2101
LID - 10.1097/MD.0000000000002101 [doi]
LID - e2101
AB  - Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease of 
      unknown etiology defined by the combination of tubulointerstitial nephritis, 
      uveitis, and biochemical abnormalities. It has been reported that TINU mainly 
      affects adolescents and young women. Here we reported a special case regarding a 
      60-year-old man with acute renal failure due to TINU syndrome documented by renal 
      biopsy.We present a rare case of an elderly patient, who had been suffering from 
      a fever for 2 weeks, characterized by sudden onset and resolving spontaneously, 
      and accompanied by extreme fatigue, loss of appetite, and shivering. Renal biopsy 
      showed a tubulointerstitial nephritis, with polymorphonuclear infiltration and 
      acute tubulitis. In the outpatient clinic, he was diagnosed with idiopathic 
      bilateral anterior uveitis 1 month ago. Ophthalmological examination revealed 
      anterior asymptomatic bilateral uveitis. Human leukocyte antigen (HLA) typing 
      (HLA-DQA1*0101/0201 and HLA-DQB1*0303/0503) was found which supported the suspect 
      of TINU syndrome. The patient was treated with oral prednisone (1 mg/kg) and 
      continued for 8 weeks on tapering doses. Serum creatinine normalized within 3 and 
      6 months later renal function also recovered completely.This case highlights that 
      TINU syndrome is probably an underdiagnosed disease responsible for some cases of 
      idiopathic anterior uveitis in elderly male patients. It is of critical 
      importance to be aware of this syndrome by nephrologist and ophthalmologists in 
      this special population. Further studies are needed to elucidate clinical 
      characteristic and pathogenesis of TINU syndrome in elderly population.
FAU - Lei, Wen-Hui
AU  - Lei WH
AD  - From the Department of Nephrology, Lishui Hospital of Zhejiang University, 
      Lishui, Zhejiang Province (W-hL, JL, M-FM, C-YZ, LJ); Department of Infection 
      Diseases and Department of Urology, The first hospital of Quanzhou affiliated to 
      Fujian Medical University, Fujian Province (X-PY, JX); and Department of 
      Radiology, Lishui Hospital of Zhejiang University, Zhejiang Province, People's 
      Republic of China (J-SJ), Department of Nephrology,Qingyuan county people's 
      hospital, Lishui, Zhejiang Province, China(C-FW).
FAU - Xin, Jun
AU  - Xin J
FAU - Yu, Xue-Ping
AU  - Yu XP
FAU - Li, Jie
AU  - Li J
FAU - Mao, Ming-Feng
AU  - Mao MF
FAU - Ji, Jian-Song
AU  - Ji JS
FAU - Wu, Chui-Fen
AU  - Wu CF
FAU - Zhu, Chao-Yong
AU  - Zhu CY
FAU - Jin, Lie
AU  - Jin L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - VB0R961HZT (Prednisone)
RN  - Tubulointerstitial nephritis and uveitis
SB  - IM
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - HLA-DQ alpha-Chains/analysis
MH  - HLA-DQ beta-Chains/analysis
MH  - Humans
MH  - Kidney Function Tests
MH  - Male
MH  - Middle Aged
MH  - Nephritis, Interstitial/*diagnosis/drug therapy
MH  - Prednisone/therapeutic use
MH  - Syndrome
MH  - Uveitis/*diagnosis/drug therapy
PMC - PMC5058994
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2015/12/04 06:00
MHDA- 2016/04/19 06:00
PMCR- 2015/10/30
CRDT- 2015/12/04 06:00
PHST- 2015/12/04 06:00 [entrez]
PHST- 2015/12/04 06:00 [pubmed]
PHST- 2016/04/19 06:00 [medline]
PHST- 2015/10/30 00:00 [pmc-release]
AID - 00005792-201511240-00049 [pii]
AID - 10.1097/MD.0000000000002101 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2015 Nov;94(47):e2101. doi: 10.1097/MD.0000000000002101.